Skip to main content

Table 4 Discriminating capacities of each query strategy

From: Assessing rare diseases prevalence using literature quantification

Prevalence Number of diseases Treshold Sensibility % [IC 95%] Specificity % [IC 95%] AUC% [IC 95%]
Query strategy 1
  < 1/1,000,000 2970     
 1–9/1,000,000 41 104.5 90.5 [85.4, 94.9] 91.9 [90.9, 92.8] 95.6 [93.9, 97.3]
 1–9/100,000 84 74.5 90.6 [84.6, 95.7] 88.7 [87.5, 89.8] 94.5 [92.2, 96.8]
 1–9/10,000 33 487 87.9 [75.8, 97] 95.2 [94.4, 95.9] 94.9 [90.2, 99.6]
Query strategy 2
  < 1/1,000,000 2970     
 1–9/1,000,000 41 74.5 78.5 [72.2; 84.8] 93.7 [92.8, 94.5] 91.9 [89.1, 94.8]
 1–9/100,000 84 74.5 78.6 [70.9; 85.5] 92.7 [91.7, 93.6] 92.2 [89.1, 95.2]
 1–9/10,000 33 93.5 81.8 [69.7; 93.9] 92.1 [91.1, 93] 92 [86.1, 98]
Query strategy 3
  < 1/1,000,000 2970     
 1–9/1,000,000 41 147.5 90.5 [86.1, 94.9] 85.4 [84.1, 86.7] 91.4 [89.4, 93.5]
 1–9/100,000 84 229 88 [82.1, 94] 86.8 [85.6, 88.1] 90.3 [87.7, 92.9]
 1–9/10,000 33 229 97 [90.9, 100] 84.9 [83.7, 86.1] 91.8 [87, 96.6]