Quality of life of children with spinal muscular atrophy and their caregivers from the perspective of caregivers: a Chinese cross-sectional study

Table 2 Average scores of proxy-reported PedsQL 3.0 Neuromuscular Module across SMA subtypes (n = 87)

Children’s QoL accessed from the caregiver	SMA Type I Mean ± SD (n = 16)	SMA Type II Mean ± SD (n = 52)	SMA Type III Mean ± SD (n = 19)	Effect size (d)
Children’s QoL accessed from the caregiver	SMA Type I Mean ± SD (n = 16)	SMA Type II Mean ± SD (n = 52)	SMA Type III Mean ± SD (n = 19)	I versus II	I versus III	II versus III
Total score	43.63 ± 13.08	48.79 ± 13.04	64.89 ± 19.75^b,c	0.39	1.08	0.82
Neuromuscular disease	40.53 ± 13.86	49.10 ± 13.65	65.32 ± 20.21^b,c	0.62	1.23	0.80
Communication	69.27 ± 33.85	71.79 ± 26.72	74.56 ± 27.70	0.07	0.16	0.10
Family resources	38.75 ± 13.60	33.94 ± 20.28	58.68 ± 26.87^b,c	0.24	0.74	0.92

Effect size (Cohen’s d) is interpreted as: 0.2 ≤ d < 0.5 small difference, 0.5 ≤ d < 0.8 moderate, and d ≥ 0.8 large
SMA spinal muscular atrophy
Bold prints indicate P < 0.05
^aPost hoc significance between type I and type II
^bPost hoc significance between type I and type III
^cPost hoc significance between type II and type III

ISSN: 1750-1172