Fig. 3

Visual comparison of gene co-expression between OP-MG and control orbicularis oculi muscles. a Ophthalmoplegic myasthenia gravis (OP-MG) orbicularis oculi muscles (OOMs) correlation plot with gene pairs (r > 0.96; p < 0.01). b Control correlation matrix (r > 0.98; p < 0.01) ordered to match hierarchical clustering configuration of A for comparison. c Gene co-expression network of OP-MG orbicularis oculi muscles (r > 0.96; p < 0.01); the OP-MG genes, identified by whole genome sequencing analysis, are labelled (intermodular gene in bold). Degree of interconnectivity is shown by increased node size. Interconnecting lines are weighted by strength of correlation. Dashed lines indicate negative correlations. The solid arrow indicates DDX17, which is central to a subnode and the most highly prioritized gene from the whole exome sequencing analysis [5]. The dashed arrow indicates PARK2 which is central to an inhibitory subnode