Table 4 Stratified associations between fibrinogen and survival
From: The prognostic role of plasma fibrinogen in adult secondary hemophagocytic lymphohistiocytosis
Subgroups | Tertile 3 | Tertile 2 | Tertile 1 | P for trend | P for interaction |
|---|---|---|---|---|---|
HR (95% CI) | HR (95% CI) | HR (95% CI) | |||
Gender | 0.800 | ||||
Male | 1.00 (Ref) | 1.02 (0.84–1.25) | 0.80 (0.65–0.98)* | 0.068 | |
Female | 1.00 (Ref) | 1.14 (0.86–1.51) | 0.86 (0.65–1.14) | 0.458 | |
Age ≤ 60 years | 0.478 | ||||
Yes | 1.00 (Ref) | 1.00 (0.79–1.28) | 0.82 (0.65–1.04) | 0.172 | |
No | 1.00 (Ref) | 1.13 (0.91–1.39) | 0.90 (0.73–1.12) | 0.480 | |
Ferritin > 10,000 ug/L | 0.855 | ||||
Yes | 1.00 (Ref) | 0.91 (0.64–1.29) | 0.89 (0.64–1.24) | 0.499 | |
No | 1.00 (Ref) | 1.12 (0.94–1.34) | 0.80 (0.67–0.97)* | 0.140 | |
sCD25 > 20,000 ug/L | 0.510 | ||||
Yes | 1.00 (Ref) | 0.93 (0.77–1.12) | 0.81 (0.67–0.97)* | 0.030 | |
No | 1.00 (Ref) | 1.49 (1.09–2.06)* | 0.97 (0.71–1.34) | 0.604 | |
EBV infection | 0.905 | ||||
Yes | 1.00 (Ref) | 0.97 (0.78–1.21) | 0.79 (0.64–0.99)* | 0.057 | |
No | 1.00 (Ref) | 1.20 (0.95–1.51) | 0.86 (0.67–1.08) | 0.531 | |
MHLH | 0.171 | ||||
Yes | 1.00 (Ref) | 1.06 (0.87–1.29) | 0.90 (0.75–1.10) | 0.378 | |
No | 1.00 (Ref) | 1.06 (0.82–1.39) | 0.72 (0.55–0.96)* | 0.080 | |