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Table 4 Stratified associations between fibrinogen and survival

From: The prognostic role of plasma fibrinogen in adult secondary hemophagocytic lymphohistiocytosis

Subgroups Tertile 3 Tertile 2 Tertile 1 P for trend P for interaction
HR (95% CI) HR (95% CI) HR (95% CI)
Gender 0.800
 Male 1.00 (Ref) 1.02 (0.84–1.25) 0.80 (0.65–0.98)* 0.068  
 Female 1.00 (Ref) 1.14 (0.86–1.51) 0.86 (0.65–1.14) 0.458  
Age ≤ 60 years 0.478
 Yes 1.00 (Ref) 1.00 (0.79–1.28) 0.82 (0.65–1.04) 0.172  
 No 1.00 (Ref) 1.13 (0.91–1.39) 0.90 (0.73–1.12) 0.480  
Ferritin > 10,000 ug/L 0.855
 Yes 1.00 (Ref) 0.91 (0.64–1.29) 0.89 (0.64–1.24) 0.499  
 No 1.00 (Ref) 1.12 (0.94–1.34) 0.80 (0.67–0.97)* 0.140  
sCD25 > 20,000 ug/L 0.510
 Yes 1.00 (Ref) 0.93 (0.77–1.12) 0.81 (0.67–0.97)* 0.030  
 No 1.00 (Ref) 1.49 (1.09–2.06)* 0.97 (0.71–1.34) 0.604  
EBV infection 0.905
 Yes 1.00 (Ref) 0.97 (0.78–1.21) 0.79 (0.64–0.99)* 0.057  
 No 1.00 (Ref) 1.20 (0.95–1.51) 0.86 (0.67–1.08) 0.531  
MHLH 0.171
 Yes 1.00 (Ref) 1.06 (0.87–1.29) 0.90 (0.75–1.10) 0.378  
 No 1.00 (Ref) 1.06 (0.82–1.39) 0.72 (0.55–0.96)* 0.080  
  1. Analyses were adjusted for age, PLT (platelet), EBV, log10-transform ferritin, MHLH and treatment strategies when they were not stratified variables
  2. Italics indicate statistical significance (P < 0.05)
  3. HR hazard ratio, CI confidence interval
  4. *P < 0.05; **P < 0.001