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Table 1  Urine creatine panel metabolites and their age and sex related distribution

From: Urine creatine metabolite panel as a screening test in neurodevelopmental disorders

Urine creatine panel metabolites Age dependent reference range Numbers Female Male Statistical analysis (non-parametric Kruskal–Wallis rank sum test)
Number Number
Mean ± SD Mean ± SD
Range Range
Urine guanidinoacetate 0–60 months (Reference range 5–150 mmol/mol creatinine) Number 58 109 p = 0.001856*
   Average ± SD 104.0 ± 51.9 81.81 ± 44.3  
   Median 100 71  
   Range 15.0–250.0 9.00–281.00  
   2.5th percentile 25 26  
   25th percentile 61 54.25  
   75th percentile 138.5 93.75  
   97.5th percentile 204.9 195.5  
  60–192 months (reference range 15–130 mmol/mol creatinine) Number 48 67 p = 0.569
   Average ± SD 64.25 ± 39.6 69.21 ± 87.8  
   Median 54 54  
   Range 8–171 1–573  
   2.5th percentile 10.275 10.625  
   25th percentile 37 34.25  
   75th percentile 85.7 78.5  
   97.5th percentile 151.625 237.025  
  192–228 months (reference range 11–60 mmol/mol creatinine) Number 6 9 p = 0.07825
   Average ± SD 60.86 ± 29.1 34.90 ± 15.8  
   Median 44 34  
   Range 29–97 13–65  
   2.5th percentile 30.35 13.9  
   25th percentile 39.5 24.5  
   75th percentile 88.5 42.75  
   97.5th percentile 96.4 61.4  
Urine creatine 0–60 months (reference range 14–830 mmol/mol creatinine) Number 58 109 p = 0.03946*
   Average ± SD 777.3 ± 490.0 645.6 ± 537.0  
   Median 720 533.5  
   Range 14.0–2333.0 4.0–3915.0  
   2.5th percentile 31.85 13.925  
   25th percentile 383 327.5  
   75th percentile 1059 885.2  
   97.5th percentile 1710.75 1844.43  
  60–192 months (reference range 16–649 mmol/mol creatinine) Number 48 67 p = 0.8339
   Average ± SD 424.83 ± 1217.0 290.8 ± 471.0  
   Median 153 161  
   Range 3.00–8756.00 3.0–3518.0  
   2.5th percentile 5.825 4  
   25th percentile 25.25 28  
   75th percentile 398.25 389  
   97.5th percentile 1080.78 907.075  
  192–228 months Number 6 9 p = 0.6594
  (reference range 19–173 mmol/mol creatinine) Average ± SD 47.0 ± 64.6 68.6 ± 164.0  
   Median 17 11  
   Range 5.0–186.0 5.0–531.0  
   2.5th percentile 5.4 5.225  
   25th percentile 9 8  
   75th percentile 51.5 16.5  
   97.5th percentile 167.1 428.625  
  1. Urine creatine panel metabolites and their age and sex related distribution in 297 patients who underwent urine creatine panel measurement for the diagnostic investigations are listed