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Table 6 Item-level coefficient of concordance for the 5-domain NPCCSS

From: Clinical disease progression and biomarkers in Niemann–Pick disease type C: a prospective cohort study

Domain Kappa coefficient of concordance
Initial rating Repeat rating
Ambulation 0.785 0.681
Cognition 0.917 0.883
Fine motor skills 0.763 0.723
Speech 0.954 0.949
Swallowing 0.813 0.858
  1. Kappa coefficients of concordance for initial and repeat ratings for each domain
  2. NPCCSS: Niemann–Pick type C disease Clinical Severity Scale