Clinical disease progression and biomarkers in Niemann–Pick disease type C: a prospective cohort study

Table 6 Item-level coefficient of concordance for the 5-domain NPCCSS

Domain	Kappa coefficient of concordance
Domain	Initial rating	Repeat rating
Ambulation	0.785	0.681
Cognition	0.917	0.883
Fine motor skills	0.763	0.723
Speech	0.954	0.949
Swallowing	0.813	0.858

Kappa coefficients of concordance for initial and repeat ratings for each domain
NPCCSS: Niemann–Pick type C disease Clinical Severity Scale

ISSN: 1750-1172