Table 4 Change in disease biomarkers over the 6–14-month observation period compared with those of healthy individuals
Skin unesterified cholesterol (μg/mg skin) | PBMC unesterified cholesterol (μg/mg protein) | Serum cholestane-triol (ng/mL) | PBMC cholesterol esterification (ng/mg protein) | PBMC HSP70 (pg/mL) | |
|---|---|---|---|---|---|
Visit 1, n | 26 | 30 | 28 | 35 | 28 |
Mean (± SD) | 2.79 (± 0.96) | 77.56 (± 21.53) | 88.31 (± 28.66) | 462.14 (± 283.60) | 1804.09 (± 713.67) |
Visit 2, n | 14 | 28 | 32 | 28 | 24 |
Mean (± SD) | 1.89 (± 0.64) | 98.45 (± 99.56) | 88.52 (± 31.56) | 616.89 (± 443.10) | 1469.94 (± 581.21) |
p value for the comparison between visits* | 0.1748 | 0.8015 | 0.3069 | 0.1212 | 0.0121 |
Change in parameter per 6 months, n | 11 | 23 | 26 | 27 | 20 |
Mean (± SD) | –0.23 (± 0.47) | 25.94 (± 97.56) | 2.64 (± 10.69) | 57.41 (± 303.81) | –225.36 (± 411.76) |
Healthy individuals, n | 6 | 6 | 3 | 37 | 19 |
Mean (± SD) | 0.36 (± 0.14) | 76.39 (± 33.82) | 5.97 (± 1.13) | 1197.15 (± 763.65) | 12,310.21 (± 4247.23) |
p values compared with healthy individuals* | 0.0006 | 0.8979 | 0.008 | < 0.0001 | < 0.0001 |