Fig. 4From: Clinical disease progression and biomarkers in Niemann–Pick disease type C: a prospective cohort studyBiomarker results at Visit 1 and Visit 2 in comparison to healthy individuals. a Median and interquartile lengths of average follow-up time. b Skin unesterified cholesterol, p = 0.0006. c PBMC unesterified cholesterol, p = 0.8979. d Serum cholestane-triol, p = 0.008. e PBMC cholesterol esterification, p < 0.0001. f PBMC HSP70, p < 0.0001. HSP70: heat shock protein 70; NPCCSS: Niemann–Pick disease type C Clinical Severity Scale; NS: not significant; PBMC: peripheral blood mononuclear cellBack to article page