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Table 5 Number of urinary extracellular vesicles (EVs) positive for EV generation, renal calcium and phosphate homeostasis regulators biomarkers from primary hyperoxaluria type 1 patients without and with nephrocalcinosis (NC) or kidney stones (KS)

From: Specific populations of urinary extracellular vesicles and proteins differentiate type 1 primary hyperoxaluria patients without and with nephrocalcinosis or kidney stones

Urinary EVs/mg creatinine Markers Primary Hyperoxaluria Type 1 (PH1) Statistical Results
PH1 without NC or KS
(n = 10)
PH1 with NC
(n = 6)
PH1 with KS
(n = 9)
p value Q value
EV generation from plasma membrane Anoctamin 4 12.6 (11.9, 13.8) 13.0 (11.7, 14.5) 11.3 (11.0, 11.6) 0.05 0.13*
Endocytosis mediated EV generation Huntington interacting protein 1 11.9 (10.6, 13.2) 11.5 (10.7, 14.1) 10.2 (9.9, 10.8) 0.14 0.17*
Renal calcium/phosphate homeostasis regulators Klotho 13.0 (12.5, 13.9) 12.3 (12.1, 14.2) 11.6 (10.3, 12.0) 0.04 0.13*
Fibroblast growth factor 23 11.4 (11.1, 11.7) 10.9 (10.5, 11.2) 10.6 (10.2, 10.9) 0.26 0.28
Phosphate transporter 1 (PiT1) 11.8 (11.5, 12.7) 11.6 (10.9, 12.1) 11.0 (10.3, 11.2) 0.15 0.19*
Phosphate transporter 2 (PiT1) 12.3 (11.5, 13.5) 12.4 (11.5, 14.2) 11.2 (10.8, 12.4) 0.11 0.17*
  1. Data are presented as median (25th and 75th percentile) of natural log of respective markers positive for urinary EVs/mg creatinine
  2. *False discovery rate (FDR) Q-value < 0.20 among PH1 patients groups