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Table 5 Number of urinary extracellular vesicles (EVs) positive for EV generation, renal calcium and phosphate homeostasis regulators biomarkers from primary hyperoxaluria type 1 patients without and with nephrocalcinosis (NC) or kidney stones (KS)

From: Specific populations of urinary extracellular vesicles and proteins differentiate type 1 primary hyperoxaluria patients without and with nephrocalcinosis or kidney stones

Urinary EVs/mg creatinine

Markers

Primary Hyperoxaluria Type 1 (PH1)

Statistical Results

PH1 without NC or KS

(n = 10)

PH1 with NC

(n = 6)

PH1 with KS

(n = 9)

p value

Q value

EV generation from plasma membrane

Anoctamin 4

12.6 (11.9, 13.8)

13.0 (11.7, 14.5)

11.3 (11.0, 11.6)

0.05

0.13*

Endocytosis mediated EV generation

Huntington interacting protein 1

11.9 (10.6, 13.2)

11.5 (10.7, 14.1)

10.2 (9.9, 10.8)

0.14

0.17*

Renal calcium/phosphate homeostasis regulators

Klotho

13.0 (12.5, 13.9)

12.3 (12.1, 14.2)

11.6 (10.3, 12.0)

0.04

0.13*

Fibroblast growth factor 23

11.4 (11.1, 11.7)

10.9 (10.5, 11.2)

10.6 (10.2, 10.9)

0.26

0.28

Phosphate transporter 1 (PiT1)

11.8 (11.5, 12.7)

11.6 (10.9, 12.1)

11.0 (10.3, 11.2)

0.15

0.19*

Phosphate transporter 2 (PiT1)

12.3 (11.5, 13.5)

12.4 (11.5, 14.2)

11.2 (10.8, 12.4)

0.11

0.17*

  1. Data are presented as median (25th and 75th percentile) of natural log of respective markers positive for urinary EVs/mg creatinine
  2. *False discovery rate (FDR) Q-value < 0.20 among PH1 patients groups