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Table 4 Number of urinary extracellular vesicles (EVs) derived from activated immune/inflammatory cells of primary hyperoxaluria type 1 patients without and with nephrocalcinosis (NC) or kidney stones (KS)

From: Specific populations of urinary extracellular vesicles and proteins differentiate type 1 primary hyperoxaluria patients without and with nephrocalcinosis or kidney stones

Urinary EVs/mg creatinine Markers Primary Hyperoxaluria Type 1 (PH1) Statistical Results
PH1 without NC or KS
(n = 10)
PH1 with NC
(n = 6)
PH1 with KS
(n = 9)
p value Q value
Total leukocyte-derived CD45 11.3 (11.1, 11.5) 11.3 (11.1, 12.7) 10.2 (10.0, 10.9) 0.03 0.13*
Neutrophil-derived CD15 11.9 (11.7, 12.5) 11.8 (11.1, 13.4) 10.6 (10.2, 11.8) 0.07 0.15*
B-lymphocyte-derived CD19 11.4 (10.9, 12.2) 11.7 (10.7, 12.9) 9.8 (9.5, 10.9) 0.04 0.13*
T-lymphocyte-derived CD3 11.2 (11.0, 11.5) 11.0 (10.8, 11.2) 10.1 (9.7, 10.8) 0.07 0.15*
Monocyte-derived CD14 11.6 (10.7, 12.4) 12.6 (11.5, 12.9) 10.3 (10.0, 11.5) 0.03 0.13*
M1-macrophage-derived CD68 11.7 (10.9, 11.9) 12.1 (11.1, 12.4) 10.5 (10.0, 11.0) 0.03 0.13*
M2-macrophage-derived CD206 11.2 (10.8, 12.2) 11.2 (10.3, 12.4) 10.2 (9.2, 10.5) 0.11 0.17*
Plasma cell-derived CD138 + CD319 10.7 (10.4, 11.8) 11.8 (10.6, 13.5) 10.2 (9.3, 10.9) 0.05 0.14*
  1. Data are presented as median (25th and 75th percentile) of natural log of respective markers positive for urinary EVs/mg creatinine
  2. *False discovery rate (FDR) Q-value < 0.20 among PH1 patients groups