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Table 2 Total number of urinary extracellular vesicles derived from cells of different segments of nephron and renal pelvis in primary hyperoxaluria type 1 patients without and with nephrocalcinosis (NC) or kidney stones (KS)

From: Specific populations of urinary extracellular vesicles and proteins differentiate type 1 primary hyperoxaluria patients without and with nephrocalcinosis or kidney stones

Urinary extracellular vesicles (EVs)/mg creatinine from specific type of cells Markers Primary Hyperoxaluria Type 1 (PH1) Statistical Results
PH-1 without NC or KS
(n = 10)
PH-1 with NC
(n = 6)
PH-1 with KS
(n = 9)
p value Q value
Microvesicles/phosphatidylserine Annexin-V 14.4 (13.8, 15.2) 13.4 (12.6, 13.9) 12.3 (11.5, 13.6) 0.13 0.16*
Exosomes CD63 14.0 (13.6, 14.4) 13.1 (12.2, 14.1) 12.8 (12.0, 13.4) 0.14 0.16*
Extracellular vesicles from glomerular cells       
Juxtaglomerular cells Beta-1 adrenergic receptor 14.7 (13.8, 14.8) 13.8 (13.2, 14.1) 12.8 (11.9, 13.8) 0.10 0.16*
Mesangial cells SM22 alpha 14.0 (12.7, 14.7) 13 (12.5, 13.2) 12.7 (11.9, 13.0) 0.06 0.13*
Podocytes Nephrin 13.7 (12.2, 14.3) 13.7 (12.5, 14.6) 12.0 (11.5, 12.7) 0.03 0.12*
Bowman’s capsule—parietal cells Cytokeratin 8 13.9 (12.7, 14.7) 13.2 (12.4, 14.0) 12.2 (11.7, 13.5) 0.26 0.28
Extracellular vesicles from different segments of nephron and renal pelvis       
Proximal tubule—simple cuboidal epithelium Urate-anion Exchanger 1 12.8 (12.1, 13.9) 11.9 (11.6, 14.2) 11.4 (10.2, 12.0) 0.01 0.11*
Megalin 14.2 (13.0, 14.6) 12.9 (12.0, 14.4) 11.9 (11.6, 13.0) 0.04 0.12*
Thin loop of Henle – simple squamous epithelium Urea Transporter (SLC14A2) 11.9 (11.4, 12.8) 11.3 (10.4, 13.3) 11.1 (10.6, 12.4) 0.64 0.64
Thick loop of Henle—simple cuboidal epithelium Uromodulin 15.0 (14.2, 15.7) 14.1 (13.1, 15.0) 12.6 (11.9, 14.4) 0.05 0.12*
Distal tubule—simple cuboidal epithelium Prominin-2 14.5 (14.0, 15.2) 13.8 (12.7, 14.5) 13.0 (12.7, 13.2) 0.03 0.12*
Collecting duct—principal cells Aquaporin-2 14.5 (13.7, 14.8) 13.8 (13.1, 14.4) 12.6 (12.0, 13.6) 0.09 0.16*
Renal pelvis—transitional epithelium Cytokeratin 20 13.9 (12.3, 14.9) 12.8 (11.4, 14.5) 11.6 (11.5, 13.4) 0.12 0.16*
  1. Data are presented as median (25th and 75th percentile) of natural log of respective markers positive for urinary EVs/mg creatinine
  2. *False discovery rate (FDR) Q-value < 0.20 among PH1 patients groups