Skip to main content

Table 2 Total number of urinary extracellular vesicles derived from cells of different segments of nephron and renal pelvis in primary hyperoxaluria type 1 patients without and with nephrocalcinosis (NC) or kidney stones (KS)

From: Specific populations of urinary extracellular vesicles and proteins differentiate type 1 primary hyperoxaluria patients without and with nephrocalcinosis or kidney stones

Urinary extracellular vesicles (EVs)/mg creatinine from specific type of cells

Markers

Primary Hyperoxaluria Type 1 (PH1)

Statistical Results

PH-1 without NC or KS

(n = 10)

PH-1 with NC

(n = 6)

PH-1 with KS

(n = 9)

p value

Q value

Microvesicles/phosphatidylserine

Annexin-V

14.4 (13.8, 15.2)

13.4 (12.6, 13.9)

12.3 (11.5, 13.6)

0.13

0.16*

Exosomes

CD63

14.0 (13.6, 14.4)

13.1 (12.2, 14.1)

12.8 (12.0, 13.4)

0.14

0.16*

Extracellular vesicles from glomerular cells

      

Juxtaglomerular cells

Beta-1 adrenergic receptor

14.7 (13.8, 14.8)

13.8 (13.2, 14.1)

12.8 (11.9, 13.8)

0.10

0.16*

Mesangial cells

SM22 alpha

14.0 (12.7, 14.7)

13 (12.5, 13.2)

12.7 (11.9, 13.0)

0.06

0.13*

Podocytes

Nephrin

13.7 (12.2, 14.3)

13.7 (12.5, 14.6)

12.0 (11.5, 12.7)

0.03

0.12*

Bowman’s capsule—parietal cells

Cytokeratin 8

13.9 (12.7, 14.7)

13.2 (12.4, 14.0)

12.2 (11.7, 13.5)

0.26

0.28

Extracellular vesicles from different segments of nephron and renal pelvis

      

Proximal tubule—simple cuboidal epithelium

Urate-anion Exchanger 1

12.8 (12.1, 13.9)

11.9 (11.6, 14.2)

11.4 (10.2, 12.0)

0.01

0.11*

Megalin

14.2 (13.0, 14.6)

12.9 (12.0, 14.4)

11.9 (11.6, 13.0)

0.04

0.12*

Thin loop of Henle – simple squamous epithelium

Urea Transporter (SLC14A2)

11.9 (11.4, 12.8)

11.3 (10.4, 13.3)

11.1 (10.6, 12.4)

0.64

0.64

Thick loop of Henle—simple cuboidal epithelium

Uromodulin

15.0 (14.2, 15.7)

14.1 (13.1, 15.0)

12.6 (11.9, 14.4)

0.05

0.12*

Distal tubule—simple cuboidal epithelium

Prominin-2

14.5 (14.0, 15.2)

13.8 (12.7, 14.5)

13.0 (12.7, 13.2)

0.03

0.12*

Collecting duct—principal cells

Aquaporin-2

14.5 (13.7, 14.8)

13.8 (13.1, 14.4)

12.6 (12.0, 13.6)

0.09

0.16*

Renal pelvis—transitional epithelium

Cytokeratin 20

13.9 (12.3, 14.9)

12.8 (11.4, 14.5)

11.6 (11.5, 13.4)

0.12

0.16*

  1. Data are presented as median (25th and 75th percentile) of natural log of respective markers positive for urinary EVs/mg creatinine
  2. *False discovery rate (FDR) Q-value < 0.20 among PH1 patients groups