Skip to main content

Table 1 Baseline clinical characteristics of study patients

From: Specific populations of urinary extracellular vesicles and proteins differentiate type 1 primary hyperoxaluria patients without and with nephrocalcinosis or kidney stones

Clinical characteristics Primary hyperoxaluria type 1 (PH1)
PH1 without NC or KS
(n = 10)
PH1 with NC
(n = 6)
PH1 with KS
(n = 9)
Total
(n = 25)
p value
Age (years) 21 (18, 25) 16 (16, 17) 20 (17, 24) 18 (16, 22) 0.13
Sex      
 Female (%) 7 (70%) 3 (50%) 2 (22%) 12 (48%) 0.14
 Male (%) 3 (30%) 3 (50%) 7 (78%) 13 (12%)  
Body mass index (kg/m2) 24 (20, 33) 24 (23, 27) 24 (22, 28) 24 (22, 29) 0.94
Systolic blood pressure (mmHg) 111 (106, 116) 112 (100, 120) 112 (105, 118) 112 (105, 118) 0.84
Diastolic blood pressure (mmHg) 73 (67, 74) 73 (51, 74) 65 (56, 68) 68 (58, 74) 0.26
Serum creatinine (mg/dL) 0.9 (0.9, 1.2) 1.1 (0.8, 1.3) 1.3 (1.1, 1.4) 1.2 (0.9, 1.3) 0.16
eGFR (mL/min/1.73 m2) 79 (73, 91) 66 (55, 94) 68 (53, 76) 73 (55, 91) 0.66
Urine biochemistry      
Urine volume (mL/24 h) 2944 (2415, 3388) 3819 (3228, 5766) 2880 (2423, 3510) 3037 (2423, 3774) 0.19
pH 6.2 (6.0, 6.6) 6.6 (6.4, 6.8) 6.3 (6.2, 6.7) 6.4 (6.2, 6.7) 0.32
Osmolality (mOsm/kg) 610 (441, 632) 286 (237, 336) 316 (183, 516) 355 (248, 610) 0.06
Calcium (mg/24 h) 96 (67, 118) 90 (47, 148) 113 (59, 126) 105 (59, 130) 0.98
Citrate (mg/24 h) 482 (273, 537) 416 (386, 533) 300 (168, 467) 384 (249, 517) 0.53
Creatinine (mg/mL) 0.52 (0.32, 0.83) 0.43 (0.28, 0.44) 0.58 (0.50, 0.71) 0.50 (0.31, 0.71) 0.59
Total protein (mg/dL) 3.5 (0.32, 7.7) 10.0 (2.5, 17.0) 1.0 (1.0, 3.0) 3.0 (1.0, 9.0) 0.29
Urine oxalate (mmol/24 h/1.73 m2) 0.60 (0.35, 1.0) 1.0 (0.8, 1.7) 1.0 (0.6, 1.4) 0.8 (0.6, 1.5) 0.32
  1. Data are presented as median (25th and 75th percentile). There were no statistically significant differences in parameters among groups (unadjusted p > 0.05)