Skip to main content

Table 1 Baseline clinical characteristics of study patients

From: Specific populations of urinary extracellular vesicles and proteins differentiate type 1 primary hyperoxaluria patients without and with nephrocalcinosis or kidney stones

Clinical characteristics

Primary hyperoxaluria type 1 (PH1)

PH1 without NC or KS

(n = 10)

PH1 with NC

(n = 6)

PH1 with KS

(n = 9)

Total

(n = 25)

p value

Age (years)

21 (18, 25)

16 (16, 17)

20 (17, 24)

18 (16, 22)

0.13

Sex

     

 Female (%)

7 (70%)

3 (50%)

2 (22%)

12 (48%)

0.14

 Male (%)

3 (30%)

3 (50%)

7 (78%)

13 (12%)

 

Body mass index (kg/m2)

24 (20, 33)

24 (23, 27)

24 (22, 28)

24 (22, 29)

0.94

Systolic blood pressure (mmHg)

111 (106, 116)

112 (100, 120)

112 (105, 118)

112 (105, 118)

0.84

Diastolic blood pressure (mmHg)

73 (67, 74)

73 (51, 74)

65 (56, 68)

68 (58, 74)

0.26

Serum creatinine (mg/dL)

0.9 (0.9, 1.2)

1.1 (0.8, 1.3)

1.3 (1.1, 1.4)

1.2 (0.9, 1.3)

0.16

eGFR (mL/min/1.73 m2)

79 (73, 91)

66 (55, 94)

68 (53, 76)

73 (55, 91)

0.66

Urine biochemistry

     

Urine volume (mL/24 h)

2944 (2415, 3388)

3819 (3228, 5766)

2880 (2423, 3510)

3037 (2423, 3774)

0.19

pH

6.2 (6.0, 6.6)

6.6 (6.4, 6.8)

6.3 (6.2, 6.7)

6.4 (6.2, 6.7)

0.32

Osmolality (mOsm/kg)

610 (441, 632)

286 (237, 336)

316 (183, 516)

355 (248, 610)

0.06

Calcium (mg/24 h)

96 (67, 118)

90 (47, 148)

113 (59, 126)

105 (59, 130)

0.98

Citrate (mg/24 h)

482 (273, 537)

416 (386, 533)

300 (168, 467)

384 (249, 517)

0.53

Creatinine (mg/mL)

0.52 (0.32, 0.83)

0.43 (0.28, 0.44)

0.58 (0.50, 0.71)

0.50 (0.31, 0.71)

0.59

Total protein (mg/dL)

3.5 (0.32, 7.7)

10.0 (2.5, 17.0)

1.0 (1.0, 3.0)

3.0 (1.0, 9.0)

0.29

Urine oxalate (mmol/24 h/1.73 m2)

0.60 (0.35, 1.0)

1.0 (0.8, 1.7)

1.0 (0.6, 1.4)

0.8 (0.6, 1.5)

0.32

  1. Data are presented as median (25th and 75th percentile). There were no statistically significant differences in parameters among groups (unadjusted p > 0.05)