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Table 3 Methods for management of urinary and bowel symptoms

From: Beyond gait and balance: urinary and bowel dysfunction in X-linked adrenoleukodystrophy

Pharmacological interventionsa Non-pharmacological interventions Lifestyle modifications
Constipation/bowel supplementsc Fiber supplements
Laxatives
Linaclotide
Loperamide
Lubiprostone
Probiotics
42.6% Leak protection pads/briefse 41.6% Restricting caffeine and/or alcohol intakeb,e 40.4%
Anti-cholinergicsd Darifenacin
Fesoterodine
Oxybutynin
Solifenacin
Tolterodine
Trospium
19.7% Catheterizationd 13.3% Limiting/modifying fluid intakee 37.1%
β3-agonistsd Mirabegron 12.7% Abdominal massageb,e 9.6% Limiting/modifying food intakee 23.6%
α-blockersd Alfuzosin
Silodosin
Tamsulosin
Terazosin
11.3% Pelvic floor physical therapye 7.9% Planning daily schedule around proximity to restroomb,e 17.3%
Cholinergic agonistsd Bethanechol 1.4%
  1. Percentage of patients in our cohort that had tried each medication, non-pharmacological intervention, and lifestyle modification to manage urinary and bowel symptoms
  2. aAmong patients with a medication record available
  3. bAmong survey respondents only
  4. cAmong patients with at least one bowel symptom
  5. dAmong patients with at least one urinary symptom
  6. eAmong patients with at least one urinary or bowel symptom