Fig. 2
Development of chronic lymphedema in a male with KHE involving the right thigh. a, b A 2-year-old boy with histopathologically confirmed KHE was treated with sirolimus for 6 months. c At 7 months after sirolimus therapy, the photograph showed tight swelling on the right side. d At 3 years of age, the photograph showed progressive swelling of the right lower extremity. Sirolimus treatment was then discontinued. e Lymphoscintigraphy showed dermal backflow and absent inguinal lymph node drainage 2 h after injection in the right limb. f At 3.5-year-old of age, treatment with a compression garment was initiated. g Twelve months after compression therapy