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Table 1 Demographic and clinical characteristics of the patients with mandibular involvement of SAPHO syndrome

From: Mandibular involvement in SAPHO syndrome: a retrospective study

Variables Mandibular involvement p valueb
+ (n = 26) − (n = 604)
Age (years), median (range) 28 (5–65) 40 (10–71) < 0.001
Sex (males/females), n (%) 10/16 (38.5/61.5) 193/411 (32.0/68.0) 0.522
Disease duration at baseline (years), median (IQR) 2 (1–8) 2 (0.6–5) 0.011
Age at onset of symptoms (years), median (IQR) 22 (14–27) 37 (29–48) < 0.001
Age at onset of oral symptoms (years), median (IQR) 25 (15–28)
Duration of diagnosis (years), median (IQR) 2 (0.8–3.0) 2 (0.7–4.7) 0.291
Dental procedurea in 1 month before the onset of oral symptoms, n (%) 10 (38.5)
Affected region of the mandible
 Left side, n (%) 7 (26.9)
 Right side, n (%) 10 (38.5)
 Bilateral, n (%) 9 (34.6)
Oral symptoms   
 Jaw pain, n (%) 24 (92.3)
 Swelling of the ipsilateral face, n (%) 22 (84.6)
 Limitation of mouth opening, n (%) 20 (76.9)
Skin manifestations, n (%) 15 (57.7) 531 (87.9) < 0.001
PPP, n (%) 8 (30.1) 490 (81.8) < 0.001
SA, n (%) 7 (26.9) 61 (10.1) 0.024
VAS, median (IQR) 5 (3–6) 4 (3–6) 0.311
Serum hs-CRP (mg/ml), median (IQR) 6.41 (2.39–21.59) 4.00 (1.95–9.03) 0.641
ESR (mm/h), median (IQR) 21 (14–31) 14 (8–28) 0.413
HLA-B27 positive, n (%) 0 (0) 27 (4.7) 0.623
  1. IQR interquartile ranges, BMI body mass index, SA severe acne, PPP palmoplantar pustulosis, VAS Visual Analogue Scale, ESR erythrocyte sedimentation rate, hs-CRP high-sensitivity C-reactive protein, HLA human leukocyte antigen
  2. aDental procedure: root canal therapy, teeth extraction, dental implant, orthodontic treatment, and gingival resection
  3. bAll the tests were two-tailed with a significance level of 0.05