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Table 1 Demographic and clinical characteristics of the patients with mandibular involvement of SAPHO syndrome

From: Mandibular involvement in SAPHO syndrome: a retrospective study

Variables

Mandibular involvement

p valueb

+ (n = 26)

− (n = 604)

Age (years), median (range)

28 (5–65)

40 (10–71)

< 0.001

Sex (males/females), n (%)

10/16 (38.5/61.5)

193/411 (32.0/68.0)

0.522

Disease duration at baseline (years), median (IQR)

2 (1–8)

2 (0.6–5)

0.011

Age at onset of symptoms (years), median (IQR)

22 (14–27)

37 (29–48)

< 0.001

Age at onset of oral symptoms (years), median (IQR)

25 (15–28)

–

–

Duration of diagnosis (years), median (IQR)

2 (0.8–3.0)

2 (0.7–4.7)

0.291

Dental procedurea in 1 month before the onset of oral symptoms, n (%)

10 (38.5)

–

–

Affected region of the mandible

–

–

 Left side, n (%)

7 (26.9)

–

–

 Right side, n (%)

10 (38.5)

–

–

 Bilateral, n (%)

9 (34.6)

–

–

Oral symptoms

  

 Jaw pain, n (%)

24 (92.3)

–

–

 Swelling of the ipsilateral face, n (%)

22 (84.6)

–

–

 Limitation of mouth opening, n (%)

20 (76.9)

–

–

Skin manifestations, n (%)

15 (57.7)

531 (87.9)

< 0.001

PPP, n (%)

8 (30.1)

490 (81.8)

< 0.001

SA, n (%)

7 (26.9)

61 (10.1)

0.024

VAS, median (IQR)

5 (3–6)

4 (3–6)

0.311

Serum hs-CRP (mg/ml), median (IQR)

6.41 (2.39–21.59)

4.00 (1.95–9.03)

0.641

ESR (mm/h), median (IQR)

21 (14–31)

14 (8–28)

0.413

HLA-B27 positive, n (%)

0 (0)

27 (4.7)

0.623

  1. IQR interquartile ranges, BMI body mass index, SA severe acne, PPP palmoplantar pustulosis, VAS Visual Analogue Scale, ESR erythrocyte sedimentation rate, hs-CRP high-sensitivity C-reactive protein, HLA human leukocyte antigen
  2. aDental procedure: root canal therapy, teeth extraction, dental implant, orthodontic treatment, and gingival resection
  3. bAll the tests were two-tailed with a significance level of 0.05