Study treatment | Geometric mean Cmax (90% CI) (μg/mL) | ΔΔQTcF Estimate (90% CI) (ms) | Concentration-QTc slope (90% CI) (ms per μg/mL) | Treatment effect-specific intercept (90% CI) (ms) |
---|---|---|---|---|
Lucerastat | ||||
1000 mg | 5.2 (4.96, 5.55) | 0.39 (− 0.13, 0.90) | 0.07 (0.01, 0.13) p = 0.0618 | 0.03 (− 0.51, 0.57) p = 0.9307 |
4000Â mg | 24. 3 (23.05, 25.68) | 1.69 (0.33, 3.05) | ||
Moxifloxacin | ||||
400 mg | 3.0 (2.78, 3.25) | 16.35 (14.03, 18.68) | 4.47 (3.58, 5.36) p < 0.0001 | 2.89 (1.82, 3.97) p < 0.0001 |