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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: The effect of the glucosylceramide synthase inhibitor lucerastat on cardiac repolarization: results from a thorough QT study in healthy subjects

Fig. 2

Change-from-baseline in HR across time points and study treatments. Mean ΔHR on lucerastat and moxifloxacin closely followed the pattern observed on placebo. a Effect of study treatments on ΔHR. b Effect of study treatments on ΔΔHR. Data expressed as LS mean and 90% CI based on a linear mixed-effects model. bpm, beats per minute; CI, confidence interval; Δ, change-from-baseline; ΔΔ, placebo-corrected change-from-baseline; HR, heart rate; LS, least squares

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