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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: The effect of the glucosylceramide synthase inhibitor lucerastat on cardiac repolarization: results from a thorough QT study in healthy subjects

Fig. 1

Plasma concentration–time profiles of lucerastat. Exposure to lucerastat increased approximately dose-proportionally and was characterized by rapid absorption and quick elimination. a Healthy male subjects after administration of 2000 and 4000 mg in Part A (N = 6). b Healthy male and female subjects after administration of 1000 and 4000 mg in Part B (N = 36). Data expressed as arithmetic mean (+ SD). N, number of subjects in the population; SD, standard deviation

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