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Table 3 Comparison between patients with and without non-sustained ventricular tachycardia

From: Myocardial disease and ventricular arrhythmia in Marfan syndrome: a prospective study

  Non-sustained ventricular tachycardia
Present (n = 20) Absent (n = 65b) p value
Female (%) 10 (50) 37 (59.7) 0.604
Age (yrs) 40.3 ± 15.7 35.2 ± 13.8 0.170
BSA (kg/m2) 21.3 (19–25.5) 21.4 (18.6–24.8) 0.821
SBP (mmHg) 124.3 ± 12.8 122.1 ± 14.5 0.549
DBP (mmHg) 67.7 ± 5.7 70.1 ± 10.9 0.365
BB use (%) 16 (80) 39 (62.9) 0.157
MFS systemic scorea 8 (4–11) 8 (6–10) 0.657
MFS group    0.008
 MFS-1 (N = 55) (%) 8 (40) 47 (72.3)  
 MFS-2 (N = 30b) (%) 12 (60) 18 (27.7)  
Cardiac ultrasound
 Ao sinus (mm) 39.9 ± 4.3 40.1 ± 5.6 0.906
 MVP (%) 7 (35) 9 (15.3) 0.058
 LVEDDi (mm/m2) 27.9 ± 3.6 24.8 ± 3.2  < 0.001
 LVESDi (mm/m2) 18.4 ± 3 16.7 ± 2.7 0.028
 LVEF (%) 63.6 ± 8.2 65.2 ± 7.4 0.419
 Mw-FS (%) 21 ± 9 19 ± 6 0.344
 RWT 0.36 (0.31–0.44) 0.35 (0.29–0.40) 0.354
 RVOTi (mm/m2) 15.9 ± 2.4 15.4 ± 2.7 0.476
 TAPSE (mm) 20.8 ± 3.7 21.7 ± 4.2 0.448
 LAVi (mm/m2) 24.2 (14–29.2) 21.2 (15.2–28.6) 0.854
 E/A ratio 1.6 ± 0.6 1.7 ± 0.6 0.723
 E/Em ratio 9.5 (7.1–11.7) 7.8 (6.6–9.7) 0.100
Serologic test
 NT-ProBNP (pg/ml) 112 (78.5–216.5) 60 (31–129) 0.017
Ambulatory ECG
 Min HR (bpm) 47 (42–51) 46 (42.2–50) 0.792
 Average HR (bpm) 67 (58–72) 65.5 (57.2–72.7) 0.991
 Max HR (bpm) 122 (100–133) 120.5 (101–142) 0.684
 QRS width (ms) 100 (90.5–109.5) 96 (82.5–101.5) 0.075
 Qtc time (ms) 426 (403–443.2) 413 (385.2–432) 0.199
 VES/24 h 345 (9–3727) 4 (1–35) 0.001
 SDNN (ms) 177 (126.1–264.6) 176 (140–203.5) 0.620
 RMSDD (ms) 74 (58–159.9) 79.5 (57.9–109) 0.790
  1. Values are given as mean ± SD, median (IQR) or number (%)
  2. Ao aortic, AoRR aortic root replacement, AR aortic regurgitation, BB beta-blocker, BSA body surface area, DBP diastolic blood pressure, ECG electrocardiogram, HR heart rate, LAVi left atrium volume index, LVEDDi left ventricular end diastolic diameter index, LVESDi left ventricular end systolic diameter index, LVEF left ventricular ejection fraction, LVMi left ventricular mass index, MFS marfan syndrome, MR mitral regurgitation, MV mitral valve, MVP mitral valve prolapse, mw-FS mid-wall fractional shortening, NSVT non-sustained ventricular, RAVi right atrium volume index, RMSDD mean squared difference of successive NN intervals, RVOT right ventricular outflow track, RWT relative wall thickness, SBP systolic blood pressure, SDNN standard deviation of the NN interval, SVES supraventricular extrasystoles, TAPSE tricuspid, annular, plane systolic excursion, VES ventricular extrasystoles
  3. aMFS systemic score is a scoring system which takes into consideration several characteristic features of MFS and assigns each of them a value between 1 and 3, 3 being the most specific for the disease. A score of ≥ 7 is considered abnormal and in combination with aortic disease and/or ectopia lentis is diagnostic of MFS
  4. bOne patient declined 24 h AECG