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Table 1 Demographic data, HHT manifestations, and gene mutations

From: Predictors of mortality in patients with hereditary hemorrhagic telangiectasia

Characteristics

Overall

Alive

Dead

Count

1286

1227

59

Age at enrollment, mean ± SD

46.0 ± 19.7

45.3 ± 19.5

60.8 ± 18.0

Age category

 

 < 20

171 (13%)

168 (14%)

3 (5%)

 20–39

263 (20%)

258 (21%)

5 (8%)

 40–59

511 (40%)

500 (41%)

11 (19%)

 > 60

341 (27%)

301 (25%)

40 (68%)

Female

749 (58%)

718 (59%)

31 (53%)

Smoker (past or current)

428/1231 (35%)

395/1178 (34%)

33/53 (62%)

Brain VM

278 (22%)

268 (22%)

10 (17%)

Pulmonary AVM

615/1235 (50%)

585/1178 (50%)

30/57 (53%)

Symptomatic liver VM

217/1217 (18%)

196/1162 (17%)

21/55 (38%)

GI bleeding

216/1233 (18%)

189/1177 (16%)

27/56 (48%)

Anemia

591/1234 (48%)

550/1181 (47%)

41/53 (77%)

Genotype

 

 ACVRL1

357/886 (40%)

343/854 (40%)

14/32 (44%)

 ENG

496/886 (56%)

482/854 (56%)

14/32 (44%)

 SMAD4

33/886 (4%)

29 (3%)

4/32 (13%)

  1. Values are n (%) or n/total (%), unless otherwise specified