Table 2 Incidence of each inherited metabolic disease among Jews versus Bedouin-Muslim population, in southern of Israel, between the years 1990 and 2017
Disease category | Overall incidence/100,000 live births | Incidence among Bedouin-Muslim/100,000 live births | Incidence among Jews/100,000 live births | P value |
|---|---|---|---|---|
Aminoacidopathy | ||||
Maple syrup urine disease (MSUD) | 4.8 | 10.2 | 0 | < 0.001 |
Non-ketotic hyperglycinemia | 3.8 | 8 | 0 | < 0.001 |
Peroxisomal diseases | ||||
X-linked Adrenoleukodystrophy | 0.8 | 0 | 1.6 | 0.1 |
Zellweger disease | 4.6 | 8.2 | 0.5 | < 0.001 |
Sphingolipidosis | ||||
Niemann Pick C type 1 | 4.8 | 9.1 | 1 | < 0.001 |
Organic aciduria | ||||
Glutaric aciduria type 1 | 2 | 4.3 | 0 | 0.003 |
Fatty acid oxidation diseases | ||||
Multiple acyl-CoA dehydrogenase deficiency | 0.5 | 1 | 0 | 0.1 |
Medium chain acyl-CoA dehydrogenase deficiency | 1 | 0.5 | 1.5 | 0.4 |
Very long chain acyl-CoA dehydrogenase deficiency | 2.3 | 4.3 | 0.5 | 0.01 |
Carnitine palmitoyl-transferase 1A | 0.3 | 0.5 | 0 | 0.3 |
Carnitine palmitoyl- transferase 2 | 0.5 | 0 | 1 | 0.2 |
Long chain 3-hydroxyl-CoA dehydrogenase deficiency | 0.5 | 0.3 | 0 | 0.3 |
Mucopolysaccharidosis | ||||
Mucopolysaccharidosis type 1 | 1 | 1.1 | 1 | 0.9 |
Mucopolysaccharidosis type 3 | 2 | 3.7 | 0.5 | 0.02 |
Mucopolysaccharidosis type 3 | 2.8 | 5.9 | 0 | < 0.001 |
Unclassified mucopolysaccharidosis | 0.8 | 1.1 | 0.5 | 0.6 |
Glycogen storage diseases | ||||
Glycogen storage disease type 0 | 0.3 | 0 | 0.5 | 0.3 |
Glycogen storage disease type 1A | 1.5 | 0 | 2.9 | 0.02 |
Glycogen Storage disease type 1B | 4.1 | 8 | 0.5 | < 0.001 |
Glycogen storage disease type IIIA | 1.8 | 0 | 3.7 | < 0.001 |
Glycogen storage disease type 6 | 2.3 | 4.8 | 0 | < 0.001 |
Glycogen storage disease type 9 | 0.3 | 0.5 | 0 | 0.3 |
Glycogen storage disease type 11 | 0.3 | 0.5 | 0 | 0.3 |
Unclassified glycogen storage disease | 0.8 | 1.1 | 0.5 | 0.6 |
Pompe disease (type 2 glycogen storage disease) | 2.3 | 4.8 | 0 | 0.003 |
Mitochondrial diseases | ||||
Complex 1 deficiency | 2.8 | 5.9 | 0 | < 0.001 |
Complex 3 deficiency | 3.3 | 7 | 0 | < 0.001 |
Complex 5 deficiency | 1.8 | 3.7 | 0 | 0.005 |
Pyruvate dehydrogenase deficiency type 1A | 0.3 | 0 | 0.5 | 0.3 |
Pyruvate dehydrogenase deficiency type E3 | 0.5 | 1.1 | 0 | 0.2 |
Kearns Sayre syndrome | 0.3 | 0 | 0.5 | 0.3 |
Mitochondrial neuro-gastrointestinal encephalopathy disease | 0.3 | 0.5 | 0 | 0.3 |
Trans-membrane protein 70 (TMEM70) deficiency | 0.5 | 1.1 | 0 | 0.2 |
Mitochondrial DNA depletion | 0.5 | 1.1 | 0 | 0.2 |
Unspecified mitochondrial disease | 0.3 | 0.5 | 0 | 0.3 |