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Table 1 Baseline patient characteristics

From: Abdominal fat pad biopsies exhibit good diagnostic accuracy in patients with suspected transthyretin amyloidosis

 

Male (n = 167)

Female (n = 107)

All (n = 274)

Age (full range)

61 (24–88) years

60 (21–86) years

60 (21–88) years

Genotype

 TTR mutation

105 (63%)

71 (66%)

176 (64%)

 V30M

101 (96%)

70 (99%)

171 (97%)

 Other

4 (4%)

1 (1%)

5 (3%)

 No TTR mutation

26 (16%)

17 (16%)

43 (16%)

 Not tested

36 (21%)

19 (18%)

55 (20%)

Symptom/findinga

 Polyneuropathy

146 (87%)

100 (93%)

246 (90%)

 Cardiomyopathy

62 (35%)

17 (16%)

79 (29%)

 GI symptoms

43 (26%)

41 (38%)

84 (31%)

 Eye complications

21 (13%)

26 (24%)

47 (17%)

 Other symptoms

1 (0.5%)

2 (2%)

3 (1%)

Echocardiogram

 IVSd ≥ 12 mm

68 (72%)

25 (45%)

93 (62%)

 IVSd < 12 mm

26 (28%)

31 (55%)

57 (38%)

99mTc-DPD scint

 Positive

18 (78%)

6 (46%)

24 (67%)

 Negative

5 (22%)

7 (54%)

12 (33%)

Amyloid in first Bx

70 (42%)

39 (36%)

109 (40%)

  1. aEach individual can present with one or more symptom/finding; Bx: biopsy; GI: gastrointestinal; IVSd: interventricular septum diameter; scint: scintigraphy; TTR: transthyretin gene. Percentages are shown as column percentage within each heading/subheading