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Fig. 4 | Orphanet Journal of Rare Diseases

Fig. 4

From: Factor XII in PMM2-CDG patients: role of N-glycosylation in the secretion and function of the first element of the contact pathway

Fig. 4

Activation by silica of plasma FXII in a control and a PMM2-CDG patient. The hypoglycosylated form detected at basal conditions in the patient had no equivalence in the heavy chain of the activated form (FXIIa), which was similar to that observed in the control. We used different concentrations of silica (a) or dextran sulfate (DXS) (b). The inactivated (fully or hypoglycosylated) FXII and the heavy chain detected after activation are pointed by arrows

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172