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Table 4 Radiological and pathological assessment in elevated-GMAb sarcoidosis and HP patients (GMAb 3.33 μg/mL) without aPAP complication

From: Clinical significance of serum anti-granulocyte–macrophage colony-stimulating factor autoantibodies in patients with sarcoidosis and hypersensitivity pneumonitis

Disease

Sarcoidosis (n = 3)

HP (n = 4)

GMAb (μg/mL)

4.43

6.33

311

4.34

7.16

8.72

8.72

Radiological findings

 GGO

+

+

+

+

+

+

 Interlobular septal thickening

+

 Crazing paving pattern

 Consolidation

 Geographic distribution

 Subpleural sparing

 Traction bronchiectasis

+

+

+

+

+

 Cyst

+

+

+

+

 Honeycombing

Pathological findings

 Eosinophilic, granular materials

+

+

 PAS staining-positive materials

 SP-A positive materials

 Foamy macrophages

+

+

 Hyaline globule/sclerotic central core

+

+

+

 Lymphocytic infiltration

+

+

+

+

+

 Interstitial fibrosis

+

+

+

+

+

+

+

 Neoplastic lesion

 Granulomatous lesion

+

+

+

+

+

+

 Neutrophilic/eosinophilic infiltration

+

+

 Necrosis

  1. Serum GMAb levels were measured at sarcoidosis or HP diagnosis
  2. aPAP autoimmune pulmonary alveolar proteinosis, GMAb anti-granulocyte–macrophage colony-stimulating factor autoantibody, HP hypersensitivity pneumonitis, GGO ground glass opacity, PAS periodic acid-Schiff, SP-A surfactant protein-A