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Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: Cost-effectiveness analysis of using the TBX6-associated congenital scoliosis risk score (TACScore) in genetic diagnosis of congenital scoliosis

Fig. 3

Two-way sensitivity analysis. a Two-way sensitivity analysis of the prevalence rate of TACS in CS versus the cost of WES. The x-axis shows the hypothesized prevalence of TACS in CS. The y-axis shows the threshold of the WES price. Above the red line, the TACScore is more cost-effective than the WES strategy. Under the red line, the WES strategy is more cost-effective than the TACScore strategy. b Two-way sensitivity analysis of the sensitivity of the TACScore versus the 1-specificity of the TACScore. The x-axis shows the hypothesized 1-specificity of the TACScore. The y-axis shows the hypothesized sensitivity of the TACScore. Above the red line, the TACScore strategy is less costly than the WES strategy. Above the blue line, the TACScore strategy is more time-saving than the WES strategy. Abbreviations: TACS, TBX6-associated congenital scoliosis; CS, congenital scoliosis; WES, whole-exome sequencing; TACScore, TBX6-associated congenital scoliosis risk score

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172