Table 2 List of final questionnaire items and source

Fatigue^{a, b}

PRO-CTCAE Symptom Term: Fatigue

Fever^a

Center specific diagnostic and treatment guidelines based on Petersdorf et al. [34]

Bleeding^{a, b}

Modified WHO Bleeding Scale [13]

Dyspnea^{a, b}

PRO-CTCAE Symptom Term: Shortness of breath

Pain^a

According to PRO-CTCAE Symptom Term: General pain

Mood^{a, b}

According to PRO-CTCAE Symptom Term: Sad; and based on an instrument by Whooley et al. [35]

Concentration/memory^{a, b}

Combination of PRO-CTCAE Symptom Term: Concentration and PRO-CTCAE Symptom Term: Memory

Palpitations^{a, b}

PRO-CTCAE Symptom Term: Heart palpitations

Gastro-intestinal problems^b

PRO-CTCAE Symptom Terms: Nausea, Vomiting, Heartburn, Gas, Bloating, Constipation and Diarrhea

Open question on other symptom

N/A

 Palpitations^a

PRO-CTCAE Symptom Term: Heart palpitations

 Tremor^a

According to CTCAE V5.0 Term: Tremor and adopted to PRO-CTCAE style

 Muscle cramps^{a, b}

According to CTCAE V5.0 Term: Muscle cramp and adopted to PRO-CTCAE style.

 Paresthesia, numbness^a

PRO-CTCAE Symptom Term: Numbness & tingling

 Trouble doing strenuous activities^b

EORTC-QLQ-C30

 Dizziness^b

PRO-CTCAE Symptom Term: Dizziness

 Hemoglobinuria^{a, b}

N/A

 Jaundice^a

N/A

 Dysphagia^{a, b}

According to CTCAE V5.0 Term: Dysphagia and adopted to the PRO-CTCAE Symptom Term: Difficulty swallowing

 Erectile dysfunction^a

PRO-CTCAE Symptom Term: Achieve and maintain erection

 Itching^b

PRO-CTCAE Symptom Term: Itching

 Pain^b

According to PRO-CTCAE Symptom Term: General pain