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Table 3 Comparison of IBEM participants without a previous fracture to IBEM participants with a previous fracturea

From: Spectrum of microarchitectural bone disease in inborn errors of metabolism: a cross-sectional, observational study

 

No Fracture

N = 75

Fracture

N = 13

p value (α = 0.05)

Radius

 Age (years)

33.3 (19.6)

30.6 (25.3)

0.712

 TtBMD (mg HA/cm3)

290.4 (81.8)

211.4 (53.5)

<0.000

 CtBMD (mg HA/cm3)

816.1 (126.5)

714.2 (109.6)

0.010

 TbBMD (mg HA/cm3)

147.1 (47.1)

121.3 (53.9)

0.077

 CtTh (mm)

0.84 (0.25)

0.68 (0.16)

0.033

 CtPo (%)

2.90 (1.94)

6.22 (5.76)

0.006

 TbN (mm-1)

1.86 (0.45)

1.73 (0.51)

0.855

 TbTh

0.07 (0.00)

0.06 (0.00)

0.009a

 TbSp (mm)

0.53 (0.24)

0.59 (0.26)

0.263

 Failure Load (N)

1714.5 (707.2)

1299.9 (640.7)

0.051

Tibia

 Age (years)

34.0 (19.4)

26.0 (24.1)

0.192

 TtBMD (mg HA/cm3)

258.5 (71.4)

205.5 (45.6)

0.012

 CtBMD (mg HA/cm3)

832.0 (103.5)

751.8 (93.9)

0.011

 TbBMD (mg HA/cm3)

138.9 (51.4)

120.9 (41.9)

0.235

 CtTh (mm)

1.10 (0.26)

0.86 (0.17)

0.002

 CtPo (%)

5.50 (3.79)

8.27 (6.01)

0.035

 TbN (mm-1)

1.58 (0.48)

1.53 (0.39)

0.918

 TbTh

0.07 (0.00)

0.06 (0.00)

0.242

 TbSp (mm)

0.75 (0.86)

0.63 (0.21)

0.932

 Failure Load (N)

4278.3 (1564.3)

3536.4 (1399.5)

0.113

  1. aData are presented as mean and standard deviation in brackets. Bold font identifies significant difference
  2. aA secondary analysis, removing participants on bone-altering drugs, revealed no significant difference between the no fracture and fracture group for TbTh (p=0.407)