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Table 3 Comparison of IBEM participants without a previous fracture to IBEM participants with a previous fracturea

From: Spectrum of microarchitectural bone disease in inborn errors of metabolism: a cross-sectional, observational study

  No Fracture
N = 75
Fracture
N = 13
p value (α = 0.05)
Radius
 Age (years) 33.3 (19.6) 30.6 (25.3) 0.712
 TtBMD (mg HA/cm3) 290.4 (81.8) 211.4 (53.5) <0.000
 CtBMD (mg HA/cm3) 816.1 (126.5) 714.2 (109.6) 0.010
 TbBMD (mg HA/cm3) 147.1 (47.1) 121.3 (53.9) 0.077
 CtTh (mm) 0.84 (0.25) 0.68 (0.16) 0.033
 CtPo (%) 2.90 (1.94) 6.22 (5.76) 0.006
 TbN (mm-1) 1.86 (0.45) 1.73 (0.51) 0.855
 TbTh 0.07 (0.00) 0.06 (0.00) 0.009a
 TbSp (mm) 0.53 (0.24) 0.59 (0.26) 0.263
 Failure Load (N) 1714.5 (707.2) 1299.9 (640.7) 0.051
Tibia
 Age (years) 34.0 (19.4) 26.0 (24.1) 0.192
 TtBMD (mg HA/cm3) 258.5 (71.4) 205.5 (45.6) 0.012
 CtBMD (mg HA/cm3) 832.0 (103.5) 751.8 (93.9) 0.011
 TbBMD (mg HA/cm3) 138.9 (51.4) 120.9 (41.9) 0.235
 CtTh (mm) 1.10 (0.26) 0.86 (0.17) 0.002
 CtPo (%) 5.50 (3.79) 8.27 (6.01) 0.035
 TbN (mm-1) 1.58 (0.48) 1.53 (0.39) 0.918
 TbTh 0.07 (0.00) 0.06 (0.00) 0.242
 TbSp (mm) 0.75 (0.86) 0.63 (0.21) 0.932
 Failure Load (N) 4278.3 (1564.3) 3536.4 (1399.5) 0.113
  1. aData are presented as mean and standard deviation in brackets. Bold font identifies significant difference
  2. aA secondary analysis, removing participants on bone-altering drugs, revealed no significant difference between the no fracture and fracture group for TbTh (p=0.407)