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Table 2 Calculation of Z-scoref for IBEM participants over the 16 years of age with age- and sex-matched controls

From: Spectrum of microarchitectural bone disease in inborn errors of metabolism: a cross-sectional, observational study

IBEM Category

TtBMD

CtBMD

TbBMD

CtTh

CtPo

TbN

TbTh

TbSp

FL

Radius

 Bone mineralization

-1.31

-2.28

-2.31

-0.54

0.26

-2.22

-1.80

4.22

-2.50b

 HPP

-1.28

-3.40

-1.11

-0.88

8.24a

-1.21

-1.08

1.42

-0.86

 LSD (skeletal)

-0.87

-2.05

-0.86

-0.87

1.00

-0.65

-0.64

1.31

-0.62

 Restricted diets

-0.97

-2.07

-1.01

-1.08

0.92

-0.97

-0.52

1.59

-1.66c

 Neuromuscular

-0.36

-1.98

-0.61

-0.15

1.86

-0.48

-0.47

1.71

-1.17

 LSD (non-skeletal)

-0.18

-0.90

-0.43

0.12

0.00

-0.62

0.66

0.70

-0.02b,c

 Osteopetrosis

+2.39

--

--

--

--

--

--

--

2.34

Tibia

 Bone mineralization

-1.39

-2.11

-2.13

-0.88

1.55

-1.65

-1.13

3.11

-2.49

 HPP

-1.12

-2.52

-0.82

-1.20

3.75d,e

-0.95

0.00

0.94

-1.24

vLSD (skeletal)

-0.94

-1.85

-0.77

-0.75

1.58

-0.51

-0.21

2.36

-1.11

 Restricted diets

-1.16

-1.47

-1.71

-0.94

0.36d

-1.07

-1.12

1.28

-1.93

 Neuromuscular

-0.94

-1.22

-1.82

-0.61

0.41

-1.58

-0.80

6.78

-2.12

 LSD (non-skeletal)

-0.49

-0.33

-0.70

-0.41

-0.24e

-0.85

-0.18

0.96

-0.83

 Osteopetrosis

--

--

--

--

--

--

--

--

--

  1. aHPP are significantly different to all other IBEM categories (with the exception of osteopetrosis), p<0.001
  2. bBone mineralization are significantly different to LSD (non-skeletal), p=0.003
  3. cRestricted diets are significantly different to LSD (non-skeletal), p=0.032
  4. dHPP are significantly different to restricted diets, p=0.043
  5. eHPP are significantly different to LSD (non-skeletal), p=0.012
  6. fZ-scores were calculated from published reference data [34]