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Table 2 Calculation of Z-scoref for IBEM participants over the 16 years of age with age- and sex-matched controls

From: Spectrum of microarchitectural bone disease in inborn errors of metabolism: a cross-sectional, observational study

IBEM Category TtBMD CtBMD TbBMD CtTh CtPo TbN TbTh TbSp FL
Radius
 Bone mineralization -1.31 -2.28 -2.31 -0.54 0.26 -2.22 -1.80 4.22 -2.50b
 HPP -1.28 -3.40 -1.11 -0.88 8.24a -1.21 -1.08 1.42 -0.86
 LSD (skeletal) -0.87 -2.05 -0.86 -0.87 1.00 -0.65 -0.64 1.31 -0.62
 Restricted diets -0.97 -2.07 -1.01 -1.08 0.92 -0.97 -0.52 1.59 -1.66c
 Neuromuscular -0.36 -1.98 -0.61 -0.15 1.86 -0.48 -0.47 1.71 -1.17
 LSD (non-skeletal) -0.18 -0.90 -0.43 0.12 0.00 -0.62 0.66 0.70 -0.02b,c
 Osteopetrosis +2.39 -- -- -- -- -- -- -- 2.34
Tibia
 Bone mineralization -1.39 -2.11 -2.13 -0.88 1.55 -1.65 -1.13 3.11 -2.49
 HPP -1.12 -2.52 -0.82 -1.20 3.75d,e -0.95 0.00 0.94 -1.24
vLSD (skeletal) -0.94 -1.85 -0.77 -0.75 1.58 -0.51 -0.21 2.36 -1.11
 Restricted diets -1.16 -1.47 -1.71 -0.94 0.36d -1.07 -1.12 1.28 -1.93
 Neuromuscular -0.94 -1.22 -1.82 -0.61 0.41 -1.58 -0.80 6.78 -2.12
 LSD (non-skeletal) -0.49 -0.33 -0.70 -0.41 -0.24e -0.85 -0.18 0.96 -0.83
 Osteopetrosis -- -- -- -- -- -- -- -- --
  1. aHPP are significantly different to all other IBEM categories (with the exception of osteopetrosis), p<0.001
  2. bBone mineralization are significantly different to LSD (non-skeletal), p=0.003
  3. cRestricted diets are significantly different to LSD (non-skeletal), p=0.032
  4. dHPP are significantly different to restricted diets, p=0.043
  5. eHPP are significantly different to LSD (non-skeletal), p=0.012
  6. fZ-scores were calculated from published reference data [34]