Bone mineral density and bone microarchitecture in a cohort of patients with Erdheim-Chester Disease

Table 2 HR-pQCT measurements in 13 ECD patients

	Tibia			Radius
	Mean ± standard deviation	Mean of adjusted value*	P-value**	Mean ± standard deviation	Mean of adjusted value*	P-value**
Bone geometry
Total area (mm2)	722.39 ± 81.79	1.003 ± 0.104	0.924	286.64 ± 61.63	0.992 ± 0.170	0.859
Cortical area (mm2)	115.01 ± 36.79	0.887 ± 0.363	0.273	60.75 ± 11.72	0.871 ± 0.204	0.032
Trabecular area (mm2)	612.07 ± 81.88	1.029 ± 0.104	0.320	229.63 ± 58.64	1.029 ± 0.199	0.599
Bone mineral density
Total BMD (mg/cm3)	383.5 ± 127.69	1.352 ± 0.521	0.023	367.96 ± 120.92	1.097 ± 0.399	0.391
Trabecular BMD (mg/cm3)	291.87 ± 146.46	2.058 ± 1.165	0.003	223.15 ± 150.06	1.529 ± 1.246	0.139
Cortical BMD (mg/cm3)	886.37 ± 83.37	0.952 ± 0.085	0.052	887.94 ± 76.93	0.955 ± 0.080	0.055
Microarchitecture measurements
Trabecular BV/TV	0.41 ± 0.2	1.876 ± 1.005	0.004	0.33 ± 0.23	1.570 ± 1.307	0.129
Trabecular number (1/mm)	1.7 ± 0.53	1.455 ± 0.469	0.002	1.58 ± 0.54	1.154 ± 0.392	0.170
Trabecular thickness (mm)	0.37 ± 0.12	1.466 ± 0.509	0.003	0.31 ± 0.17	1.361 ± 0.783	0.110
Trabecular spacing (mm)	0.60 ± 0.20	0.865 ± 0.293	0.109	0.68 ± 0.36	0.977 ± 0.464	0.858
Standard deviation of 1/trabecular number	0.25 ± 0.09	0.763 ± 0.274	0.005	0.30 ± 0.22	1.124 ± 0.721	0.540
Cortical thickness (mm)	1.30 ± 0.42	0.909 ± 0.343	0.348	1.03 ± 0.20	0.887 ± 0.189	0.041
Cortical porosity (%)	0.02 ± 0.02	1.346 ± 0.904	0.180	0.01 ± 0.01	1.854 ± 2.312	0.196

^a The adjusted value was the quotient of the measurements and that of the reference normal mean, which derived from an ongoing population-based study of HR-pQCT in Chinese population [19]. Details of fitted distribution model was listed in supplementary document
^b p-value: one sample t-test
Abbreviations: BMD, bone mineral density; BV/TV, bone volume to tissue volume fraction;

ISSN: 1750-1172