Skip to main content

Table 2 HR-pQCT measurements in 13 ECD patients

From: Bone mineral density and bone microarchitecture in a cohort of patients with Erdheim-Chester Disease

  Tibia Radius
Mean ± standard deviation Mean of adjusted value* P-value** Mean ± standard deviation Mean of adjusted value* P-value**
Bone geometry
 Total area (mm2) 722.39 ± 81.79 1.003 ± 0.104 0.924 286.64 ± 61.63 0.992 ± 0.170 0.859
 Cortical area (mm2) 115.01 ± 36.79 0.887 ± 0.363 0.273 60.75 ± 11.72 0.871 ± 0.204 0.032
 Trabecular area (mm2) 612.07 ± 81.88 1.029 ± 0.104 0.320 229.63 ± 58.64 1.029 ± 0.199 0.599
Bone mineral density
 Total BMD (mg/cm3) 383.5 ± 127.69 1.352 ± 0.521 0.023 367.96 ± 120.92 1.097 ± 0.399 0.391
 Trabecular BMD (mg/cm3) 291.87 ± 146.46 2.058 ± 1.165 0.003 223.15 ± 150.06 1.529 ± 1.246 0.139
 Cortical BMD (mg/cm3) 886.37 ± 83.37 0.952 ± 0.085 0.052 887.94 ± 76.93 0.955 ± 0.080 0.055
Microarchitecture measurements
 Trabecular BV/TV 0.41 ± 0.2 1.876 ± 1.005 0.004 0.33 ± 0.23 1.570 ± 1.307 0.129
 Trabecular number (1/mm) 1.7 ± 0.53 1.455 ± 0.469 0.002 1.58 ± 0.54 1.154 ± 0.392 0.170
 Trabecular thickness (mm) 0.37 ± 0.12 1.466 ± 0.509 0.003 0.31 ± 0.17 1.361 ± 0.783 0.110
 Trabecular spacing (mm) 0.60 ± 0.20 0.865 ± 0.293 0.109 0.68 ± 0.36 0.977 ± 0.464 0.858
 Standard deviation of 1/trabecular number 0.25 ± 0.09 0.763 ± 0.274 0.005 0.30 ± 0.22 1.124 ± 0.721 0.540
 Cortical thickness (mm) 1.30 ± 0.42 0.909 ± 0.343 0.348 1.03 ± 0.20 0.887 ± 0.189 0.041
 Cortical porosity (%) 0.02 ± 0.02 1.346 ± 0.904 0.180 0.01 ± 0.01 1.854 ± 2.312 0.196
  1. a The adjusted value was the quotient of the measurements and that of the reference normal mean, which derived from an ongoing population-based study of HR-pQCT in Chinese population [19]. Details of fitted distribution model was listed in supplementary document
  2. b p-value: one sample t-test
  3. Abbreviations: BMD, bone mineral density; BV/TV, bone volume to tissue volume fraction;