Retained primary teeth in STAT3 hyper-IgE syndrome: early intervention in childhood is essential

Table 1 Dental and oral findings of STAT3-HIES patients

ID	Age [years]	Gender	retained primary teeth	extracted primary teeth (No.)	delayed resorption of primary teeth (as to X-ray)	oral candidiasis	gingivitis	aphthous ulcers	abnormal dental anatomy	other findings	Heterozygous STAT3 mutation
#1	37	female	no	no	no	yes	no	no	no	no	c.1144C > T; p.R382W
#2	5	male	N/A	N/A	no X-ray available	no	no	no	no	median rhomboid glossitis	c.1144C > T; p.R382W
#3	17	male	yes	yes (18)	yes	yes	no	yes	no	no	c.1145G > A; p.R382Q
#4	12	female	yes	yes (20)	yes	yes	no	no	yes	agenesis of 2 premolars	c.1909G > A; p.V637M
#5	32	male	no	no	no	no	yes	no	no	no	c.1152 T > A; p.F348L
#6	16	female	yes	yes (20)	yes	no	no	no	no	no	c.1145G > A; p.R382Q
#7	19	female	yes	yes (7)	yes	no	no	no	yes	abnormal shaped premolar	c.2114 A > C; p.Y705C
#8	23	female	yes	yes [4]	yes	no	no	yes	no	no	c.1406A > G; p.Q469R
#9	24	female	yes	yes (20)	yes	yes	yes	no	no	no	c.1145G > A; p.R382Q
#10	7	male	yes	yes (2)	no X-ray available	no	yes	no	no	no	c.1145G > A; p.R382Q
#11	9	male	yes	yes (5)	yes	yes	yes	no	no	no	c.1145G > A; p.R382Q
#12	8	male	yes	yes (1)	yes	yes	no	no	yes	agenesis of 1 premolar	c.1144C > T; p.R382W
#13	48	male	yes	no	no X-ray available	yes	no	no	no	no	c.1144C > T; p.R382W
Positive for finding:			83%	75%	80%	54%	31%	15%	15%	8%

ISSN: 1750-1172