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Table 5 Laboratory abnormalities at hospital admission related to death within 7 days and within 30 days among 160 pediatric HLH patients

From: Clinical profiles and risk factors of 7-day and 30-day mortality among 160 pediatric patients with hemophagocytic lymphohistiocytosis

Laboratory abnormalities a

Death within 30 days (n = 46)

Death within 7 days (n = 18)

OR (95%CI)

p value

OR (95%CI)

p value

BUN > 6.4 mmol/L

3.02 (1.15, 7.94)

0.0251

5.53 (1.83, 16.75)

0.0025

APTT > 48 s

4.39 (1.87, 10.33)

0.0007

13.03 (1.69, 100.69)

0.0139

PT > 14 s

6.94 (2.31, 20.84)

0.0005

9.17 (1.18, 71.01)

0.0339

INR > 1.5

5.52 (2.53, 12.02)

< 0.0001

13.62 (4.16, 44.62)

< 0.0001

FIB ≤150 mg/dL

2.55 (1.14, 5.71)

0.0226

2.19 (0.68, 7.02)

0.1861

Tbil > 19 μmol/L

2.43 (1.18, 4.99)

0.0154

2.57 (0.91, 7.24)

0.0747

Globulin < 20 g/L

2.27 (1.02, 5.05)

0.0444

1.72 (0.59, 5.02)

0.3202

  1. APTT = activated partial thromboplastin time. BUN = blood urea nitrogen. FIB = fibrinogen. INR = international normalized ratio. PT = prothrombin time. Tbil = total bilirubin
  2. a. Only presents tests that were found to be significantly associated with 7-day and/or 30 day mortality (p < 0.05)
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172