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Table 5 Laboratory abnormalities at hospital admission related to death within 7 days and within 30 days among 160 pediatric HLH patients

From: Clinical profiles and risk factors of 7-day and 30-day mortality among 160 pediatric patients with hemophagocytic lymphohistiocytosis

Laboratory abnormalities a Death within 30 days (n = 46) Death within 7 days (n = 18)
OR (95%CI) p value OR (95%CI) p value
BUN > 6.4 mmol/L 3.02 (1.15, 7.94) 0.0251 5.53 (1.83, 16.75) 0.0025
APTT > 48 s 4.39 (1.87, 10.33) 0.0007 13.03 (1.69, 100.69) 0.0139
PT > 14 s 6.94 (2.31, 20.84) 0.0005 9.17 (1.18, 71.01) 0.0339
INR > 1.5 5.52 (2.53, 12.02) < 0.0001 13.62 (4.16, 44.62) < 0.0001
FIB ≤150 mg/dL 2.55 (1.14, 5.71) 0.0226 2.19 (0.68, 7.02) 0.1861
Tbil > 19 μmol/L 2.43 (1.18, 4.99) 0.0154 2.57 (0.91, 7.24) 0.0747
Globulin < 20 g/L 2.27 (1.02, 5.05) 0.0444 1.72 (0.59, 5.02) 0.3202
  1. APTT = activated partial thromboplastin time. BUN = blood urea nitrogen. FIB = fibrinogen. INR = international normalized ratio. PT = prothrombin time. Tbil = total bilirubin
  2. a. Only presents tests that were found to be significantly associated with 7-day and/or 30 day mortality (p < 0.05)