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Table 4 Factors significantly associated with death within 7 days and within 30 days among 160 pediatric HLH patients

From: Clinical profiles and risk factors of 7-day and 30-day mortality among 160 pediatric patients with hemophagocytic lymphohistiocytosis

Factor a Death within 30 days Death within 7 days
OR (95%CI) p value OR (95%CI) p value
Age, ≤ 1 year versus > 1 years 1.77 (0.73, 4.31) 0.2076 3.53 (1.17, 10.67) 0.0253
Admission to PICU 3.24 (1.59, 6.64) 0.0013 2.49 (0.91, 6.8) 0.0761
Underlying diseases and concomitant diagnosis
 EBV infection 0.51 (0.25, 1.02) 0.0581 0.27 (0.09, 0.81) 0.0191
 Sepsis 5.37 (2.21, 13.05) 0.0002 13.17 (1.71, 101.72) 0.0134
 Other infections 0.36 (0.15, 0.88) 0.0254 0.13 (0.02, 1.02) 0.0518
 Myocardial damage 11.76 (5.18, 26.68) < 0.0001 19.05 (4.19, 86.53) 0.0001
 Heart failure 6.3 (2.61, 15.18) < 0.0001 4.88 (1.72, 13.85) 0.0029
 Shock 9.97 (3.36, 29.61) < 0.0001 16.5 (5.33, 51.09) < 0.0001
 CNS disease 5.75 (2.62, 12.6) < 0.0001 3.73 (1.36, 10.23) 0.0104
 Hepatic dysfunction 8.51 (3.12, 23.18) < 0.0001 - b 0.9346
 Severe pneumonia 11.95 (5.21, 27.44) < 0.0001 5.09 (1.71, 15.12) 0.0034
 Respiratory failure 14.98 (6.21, 36.15) < 0.0001 15.66 (3.46, 70.9) 0.0004
 ARDS 9.72 (2.53, 37.3) 0.0009 4.22 (1.15, 15.5) 0.0299
 Coagulopathy 14.51 (5.29, 39.75) < 0.0001 0.9272
 DIC 6.85 (3.12, 15.03) < 0.0001 7.47 (2.59, 21.54) 0.0002
 Acute kidney injury 7.2 (2.37, 21.92) 0.0005 8.34 (2.65, 26.2) 0.0003
 Gastrointestinal disorder 12.5 (4.96, 31.47) < 0.0001 4.14 (1.48, 11.61) 0.0069
 MODS 17.58 (5.87, 52.71) < 0.0001 - b 0.9275
 Immunodeficiency 3.52 (1.62, 7.64) 0.0015 1.79 (0.62, 5.16) 0.2805
HLH therapies
 Etoposide 0.1 (0.05, 0.23) < 0.0001 0.02 (0, 0.17) 0.0002
 Cyclosporine A 0.31 (0.15, 0.67) 0.0026 0.26 (0.1, 0.71) 0.0089
 Dexamethasone 0.3 (0.13, 0.68) 0.0041 0.16 (0.06, 0.45) 0.0005
  1. ARDS = acute respiratory distress syndrome. DIC = disseminated intravascular coagulation. EBV = Epstein-Barr Virus. MODS = multiple organ dysfunction syndrome
  2. a. Only presents factors that were found to be significantly associated with 7-day and/or 30-day mortality (p < 0.05)
  3. b. ORs could not be estimated because all patients in this group developed hepatic dysfunction, coagulopathy, and MODS