|
Factor a
|
Death within 30 days
|
Death within 7 days
|
|---|
|
OR (95%CI)
|
p value
|
OR (95%CI)
|
p value
|
|---|
|
Age, ≤ 1 year versus > 1 years
|
1.77 (0.73, 4.31)
|
0.2076
|
3.53 (1.17, 10.67)
|
0.0253
|
|
Admission to PICU
|
3.24 (1.59, 6.64)
|
0.0013
|
2.49 (0.91, 6.8)
|
0.0761
|
|
Underlying diseases and concomitant diagnosis
|
|
EBV infection
|
0.51 (0.25, 1.02)
|
0.0581
|
0.27 (0.09, 0.81)
|
0.0191
|
|
Sepsis
|
5.37 (2.21, 13.05)
|
0.0002
|
13.17 (1.71, 101.72)
|
0.0134
|
|
Other infections
|
0.36 (0.15, 0.88)
|
0.0254
|
0.13 (0.02, 1.02)
|
0.0518
|
|
Myocardial damage
|
11.76 (5.18, 26.68)
|
< 0.0001
|
19.05 (4.19, 86.53)
|
0.0001
|
|
Heart failure
|
6.3 (2.61, 15.18)
|
< 0.0001
|
4.88 (1.72, 13.85)
|
0.0029
|
|
Shock
|
9.97 (3.36, 29.61)
|
< 0.0001
|
16.5 (5.33, 51.09)
|
< 0.0001
|
|
CNS disease
|
5.75 (2.62, 12.6)
|
< 0.0001
|
3.73 (1.36, 10.23)
|
0.0104
|
|
Hepatic dysfunction
|
8.51 (3.12, 23.18)
|
< 0.0001
|
- b
|
0.9346
|
|
Severe pneumonia
|
11.95 (5.21, 27.44)
|
< 0.0001
|
5.09 (1.71, 15.12)
|
0.0034
|
|
Respiratory failure
|
14.98 (6.21, 36.15)
|
< 0.0001
|
15.66 (3.46, 70.9)
|
0.0004
|
|
ARDS
|
9.72 (2.53, 37.3)
|
0.0009
|
4.22 (1.15, 15.5)
|
0.0299
|
|
Coagulopathy
|
14.51 (5.29, 39.75)
|
< 0.0001
|
–
|
0.9272
|
|
DIC
|
6.85 (3.12, 15.03)
|
< 0.0001
|
7.47 (2.59, 21.54)
|
0.0002
|
|
Acute kidney injury
|
7.2 (2.37, 21.92)
|
0.0005
|
8.34 (2.65, 26.2)
|
0.0003
|
|
Gastrointestinal disorder
|
12.5 (4.96, 31.47)
|
< 0.0001
|
4.14 (1.48, 11.61)
|
0.0069
|
|
MODS
|
17.58 (5.87, 52.71)
|
< 0.0001
|
- b
|
0.9275
|
|
Immunodeficiency
|
3.52 (1.62, 7.64)
|
0.0015
|
1.79 (0.62, 5.16)
|
0.2805
|
|
HLH therapies
|
|
Etoposide
|
0.1 (0.05, 0.23)
|
< 0.0001
|
0.02 (0, 0.17)
|
0.0002
|
|
Cyclosporine A
|
0.31 (0.15, 0.67)
|
0.0026
|
0.26 (0.1, 0.71)
|
0.0089
|
|
Dexamethasone
|
0.3 (0.13, 0.68)
|
0.0041
|
0.16 (0.06, 0.45)
|
0.0005
|
- ARDS = acute respiratory distress syndrome. DIC = disseminated intravascular coagulation. EBV = Epstein-Barr Virus. MODS = multiple organ dysfunction syndrome
- a. Only presents factors that were found to be significantly associated with 7-day and/or 30-day mortality (p < 0.05)
- b. ORs could not be estimated because all patients in this group developed hepatic dysfunction, coagulopathy, and MODS
