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Fig. 5 | Orphanet Journal of Rare Diseases

Fig. 5

From: Multi-level consistent changes of the ECM pathway identified in a typical keratoconus twin’s family by multi-omics analysis

Fig. 5

Consistent changes of the ECM pathway identified by multi-omics analysis. a Top ten enriched GOs (each category) of 300 downregulated genes. b Top ten enriched GOs (each category) of 289 upregulated genes. c TOP 20 enriched KEGG pathways of differentially expressed genes. d TOP 20 enriched Reactome pathways of differentially expressed genes. e The shared GOs of candidate variant genes and differentially expressed genes. The GOs having similar functions with the reported pathogenesis of KC are indicated by red color. f The shared KEGG and Reactome pathways of candidate variant genes and differentially expressed genes. The pathways having similar functions with the reported pathogenesis of KC are indicated by red color

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172