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Fig. 4 | Orphanet Journal of Rare Diseases

Fig. 4

From: Multi-level consistent changes of the ECM pathway identified in a typical keratoconus twin’s family by multi-omics analysis

Fig. 4

Expression and function analysis of the candidate genes and their top 20 associated genes. a 589 differentially expressed genes in KC HCF cells detected by transcriptome sequencing. b Expression and function analysis of the PKDREJ and its top 20 associated genes. c Expression and function analysis of the FGA and its top 20 associated genes. d Expression and function analysis of the candidate genes (inner ring) under the polygenetic model and their top 20 associated genes (outer ring). FPKM values of each gene in proband (left) and normal (right) HCF cells of were showed. Asterisk represents a significant difference (red color) (*, p < 0 .05; **, p < 0 .01; ***, p < 0 .01). ND, not detected

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172