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Table 2 Univariate and multivariate analyses of factors which affect the outcome of HLH

From: A novel prognostic model for adult patients with Hemophagocytic Lymphohistiocytosis

Variables

Univariate analysis

Multivariate analysis

HR

95% CI

P value

β

HR

95% CI

P-value

Ferritin

0.070

0.026–0.184

< 0.001

−2.290

0.101

0.036–0.282

< 0.001

Neutrophils

3.414

1.400–8.325

0.007

    

HB

3.251

1.577–6.703

0.002

    

Platelets

6.364

2.840–14.260

< 0.001

1.568

4.799

1.884–12.223

0.001

ALT

0.298

0.147–0.607

0.001

−0.860

0.423

0.180–0.997

0.049

AST

0.409

0.203–0.824

0.015

    

LDH

0.321

0.147–0.699

0.005

    

α-HBDH

0.231

0.101–0.530

< 0.001

    

DBIL

0.262

0.129–0.543

< 0.001

    

Albumin

9.684

1.176–79.738

0.010

    

UREA

0.235

0.103–0.533

< 0.001

    

CREA

0.085

0.011–0.680

0.001

    

UA

0.334

0.136–0.821

0.020

    

Ca2+

4.593

1.949–10.824

< 0.001

    

AUC

 

0.842

     
  1. ALT alanine aminotransferase, AUC area under the curve, CA calcium, CREA creatinine, CI confidence interval, DBIL direct bilirubin, HB hemoglobin, α-HBDH hydroxybutyrate dehydrogenase, HR hazard ratio, LDL low density lipoprotein, UREA urea nitrogen, β regression coefcient