Fig. 2
From: Childhood Langerhans cell histiocytosis with severe lung involvement: a nationwide cohort study
Intensive care unit (ICU) hospitalizations and management for 17 patients with pulmonary Langerhans cell histiocytosis. Solid bars represent one ICU stay, and the length of stay is proportional to the scale bar (each section on the X-axis = 20 days). Bracketed numbers are the number of days between ICU stays. □ indicates death. Pulmonary lesions associated with respiratory failure are indicated with shading (black: pneumothorax; dark grey: severe cystic lung lesion without pneumothorax; light grey: diffuse micronodular lung infiltration). Anti-LCH treatments are specified above each ICU stay, and the treatment time is indicated with lines (VC: vinblastine corticosteroid; VP16 Ara-C: Etoposide-Cytarabine; 2CDA: Cladribine; Mek i: MEK inhibitor; BRAF i: BRAF inhibitor). Points before or following the lines indicate ongoing treatments for unspecified times. Pneumothorax treatments are indicated under each ICU stay (D: drainage, T: talcage, P: pleurectomy by thoracotomy)