Pattern A2: MR images of a late-infantile patient in the disease course. Patient 28 (onset 9 months). At 11.5 months, the central white matter does, while cerebellar white matter does not show abnormalities (a). One and 1 ½ months later, parieto-occipital white matter is increasingly involved, the cerebellar white matter still not affected (b,c). Six months later, frontal, central and parieto-occipital white matter as well as cerebellum are affected (d).