Fig. 8From: Natural history of Krabbe disease – a nationwide study in Germany using clinical and MRI dataPattern A1 (early-infantile form) at an advanced stage. Axial images (T2w left, Flair right) show cystic degeneration of the pyramidal tract (white arrows), severe atrophy with enlarged insulae and diffusely affected white matter. Patient 12 (onset 4 months, age at MRI 8 months).Back to article page