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Table 4 Results of the TAND Checklist applied to the NF1 Cohort, based on clinical severity

From: The TAND checklist: a useful screening tool in children with tuberous sclerosis and neurofibromatosis type 1

Neuropsychiatric manifestations General Severity NF1 (Riccardi)
MINIMAL (n = 19)(45.2%) MILD(n = 15)(35.7%) MODERATESEVERE(n = 8)(19.1%) X2 p value
n (%) n (%) n (%)
Behavioral level
 Anxiety 9 (47.4) 9 (60.0) 3 (37.5) 1.153 0.562
 Depressed mood 3 (15.8) 4 (26.7) 2 (25.0) 0.664 0.718
 Extreme shyness 4 (21.1) 3 (20.0) 0 (0.0) 1.983 0.371
 Mood swings 5 (26.3) 5 (33.3) 1 (12.5) 1.172 0.557
 Aggressive outbursts 4 (21.1) 3 (20.0) 1 (12.5) 0.281 0.869
 Temper tantrums 9 (47.4) 3 (20.0) 4 (50.0) 3.256 0.196
 Self-injury 1 (5.3) 0 (0.0) 0 (0.0) 1.240 0.538
 Absent or delayed onset of language 3 (15.8) 3 (20.0) 0 (0.0) 1.768 0.413
 Repetitive language 3 (15.8) 1 (6.7) 0 (0.0) 1.850 0.397
 Poor eye contact 2 (10.5) 0 (0.0) 0 (0.0) 2.542 0.281
 Difficult relationship with peers 3 (15.8) 3 (20.0) 0 (0.0) 1.768 0.413
 Repetitive behaviors 1 (5.3) 1 (6.7) 1 (12.5) 0.452 0.798
 Rigidity 4 (21.1) 4 (26.7) 3 (37.5) 0.791 0.673
 Overactivity/hyperactivity 8 (42.1) 6 (40.0) 2 (25.0) 0.734 0.693
 Difficulty paying attention or concentrating 14 (73.7) 6 (40.0) 5 (62.5) 3.984 0.136
 Restlessness 4 (21.1) 4 (26.7) 0 (0.0) 2.497 0.287
 Impulsivity 12 (63.2) 8 (53.3) 2 (25.0) 3.295 0.193
 Difficulties with eating 6 (31.6) 4 (26.7) 3 (37.5) 0.293 0.864
 Sleep difficulties 8 (42.1) 3 (20.0) 1 (12.5) 3.258 0.196
Scholastic level
 Reading 7 (36.8) 6 (40.0) 1 (12.5) 2.713 0.607
 Writing 12 (63.2) 4 (26.7) 3 (37.5) 4.810 0.307
 Spelling 7 (36.8) 8 (53.3) 2 (25.0) 1.929 0.381
 Mathematics 8 (42.1) 7 (46.7) 5 (62.5) 2.209 0.697
Neuropsychological level
 Memory 5 (26.3) 4 (26.7) 3 (37.5) 0.387 0.824
 Attention 14 (73.7) 6 (40.0) 5 (62.5) 3.984 0.136
 Dual-tasking 7 (36.8) 6 (40.0) 3 (37.5) 0.037 0.982
 Visuo-spatial tasks 1 (5.3) 2 (13.3) 1 (12.5) 0.735 0.692
 Executive skills 7 (36.8) 5 (33.3) 4 (50.0) 0.638 0.727
 Getting disoriented 3 (15.8) 1 (6.7) 0 (0.0) 1.850 0.397
Psychosocial level
 Low self-esteem 8 (42.1) 4 (26.7) 3 (37.5) 0.884 0.643
 Very high levels of stress in families 6 (31.6) 5 (33.3) 3 (37.5) 0.089 0.957
 Very high levels of stress between parents 3 (15.8) 2 (13.3) 3 (37.5) 2.215 0.330