Table 4 Results of the TAND Checklist applied to the NF1 Cohort, based on clinical severity
Neuropsychiatric manifestations | General Severity NF1 (Riccardi) | ||||
|---|---|---|---|---|---|
MINIMAL (n = 19)(45.2%) | MILD(n = 15)(35.7%) | MODERATESEVERE(n = 8)(19.1%) | X2 | p value | |
n (%) | n (%) | n (%) | |||
Behavioral level | |||||
 Anxiety | 9 (47.4) | 9 (60.0) | 3 (37.5) | 1.153 | 0.562 |
 Depressed mood | 3 (15.8) | 4 (26.7) | 2 (25.0) | 0.664 | 0.718 |
 Extreme shyness | 4 (21.1) | 3 (20.0) | 0 (0.0) | 1.983 | 0.371 |
 Mood swings | 5 (26.3) | 5 (33.3) | 1 (12.5) | 1.172 | 0.557 |
 Aggressive outbursts | 4 (21.1) | 3 (20.0) | 1 (12.5) | 0.281 | 0.869 |
 Temper tantrums | 9 (47.4) | 3 (20.0) | 4 (50.0) | 3.256 | 0.196 |
 Self-injury | 1 (5.3) | 0 (0.0) | 0 (0.0) | 1.240 | 0.538 |
 Absent or delayed onset of language | 3 (15.8) | 3 (20.0) | 0 (0.0) | 1.768 | 0.413 |
 Repetitive language | 3 (15.8) | 1 (6.7) | 0 (0.0) | 1.850 | 0.397 |
 Poor eye contact | 2 (10.5) | 0 (0.0) | 0 (0.0) | 2.542 | 0.281 |
 Difficult relationship with peers | 3 (15.8) | 3 (20.0) | 0 (0.0) | 1.768 | 0.413 |
 Repetitive behaviors | 1 (5.3) | 1 (6.7) | 1 (12.5) | 0.452 | 0.798 |
 Rigidity | 4 (21.1) | 4 (26.7) | 3 (37.5) | 0.791 | 0.673 |
 Overactivity/hyperactivity | 8 (42.1) | 6 (40.0) | 2 (25.0) | 0.734 | 0.693 |
 Difficulty paying attention or concentrating | 14 (73.7) | 6 (40.0) | 5 (62.5) | 3.984 | 0.136 |
 Restlessness | 4 (21.1) | 4 (26.7) | 0 (0.0) | 2.497 | 0.287 |
 Impulsivity | 12 (63.2) | 8 (53.3) | 2 (25.0) | 3.295 | 0.193 |
 Difficulties with eating | 6 (31.6) | 4 (26.7) | 3 (37.5) | 0.293 | 0.864 |
 Sleep difficulties | 8 (42.1) | 3 (20.0) | 1 (12.5) | 3.258 | 0.196 |
Scholastic level | |||||
 Reading | 7 (36.8) | 6 (40.0) | 1 (12.5) | 2.713 | 0.607 |
 Writing | 12 (63.2) | 4 (26.7) | 3 (37.5) | 4.810 | 0.307 |
 Spelling | 7 (36.8) | 8 (53.3) | 2 (25.0) | 1.929 | 0.381 |
 Mathematics | 8 (42.1) | 7 (46.7) | 5 (62.5) | 2.209 | 0.697 |
Neuropsychological level | |||||
 Memory | 5 (26.3) | 4 (26.7) | 3 (37.5) | 0.387 | 0.824 |
 Attention | 14 (73.7) | 6 (40.0) | 5 (62.5) | 3.984 | 0.136 |
 Dual-tasking | 7 (36.8) | 6 (40.0) | 3 (37.5) | 0.037 | 0.982 |
 Visuo-spatial tasks | 1 (5.3) | 2 (13.3) | 1 (12.5) | 0.735 | 0.692 |
 Executive skills | 7 (36.8) | 5 (33.3) | 4 (50.0) | 0.638 | 0.727 |
 Getting disoriented | 3 (15.8) | 1 (6.7) | 0 (0.0) | 1.850 | 0.397 |
Psychosocial level | |||||
 Low self-esteem | 8 (42.1) | 4 (26.7) | 3 (37.5) | 0.884 | 0.643 |
 Very high levels of stress in families | 6 (31.6) | 5 (33.3) | 3 (37.5) | 0.089 | 0.957 |
 Very high levels of stress between parents | 3 (15.8) | 2 (13.3) | 3 (37.5) | 2.215 | 0.330 |