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Table 2 Clinical characteristics of the NF1 Cohort

From: The TAND checklist: a useful screening tool in children with tuberous sclerosis and neurofibromatosis type 1

  NF1 patients
(n = 42)
Mean age (years) ± SD 11.33 ± 4.25  
Range 4–20  
  n (%)
Gender
 Male 19 (45.2%)
 Female 23 (54.8%)
Clinical criteria met for NF1 42 (100%)
OPG (Optic Pathway Glioma) 14 (33.3%)
 Stable OPG on brain MRI 11 (78.6%)
 Regressed OPG on brain MRI 2 (14.3%)
 Worsened OPG on brain MRI 1 (7.1%)
Other CNS tumors 5 (11.9%)
 Neurosurgical treatment 2 (40.0%)
 Chemotherapy 1 (20.0%)
Plexiform neurofibromas (NF) 12 (28.6%)
Plexiform NF treated with surgery 2 (16.6%)
Received IQ assessment 42 (100%)
Median IQ ± SD Range 94.32 ± 14.89 59–113  
 Normal IQ 33 (78.6%)
 BIF 5 (11.9%)
 Mild ID 4 (9.5%)
 Moderate/severe ID 0 (0.0%)
Received formal psychiatric assessmen 15 (35.7%)
 ASD 0 (0.0%)
 ADHD 7 (46.6%)
 Anxious/Depressed Disorder 5 (33.3%)
Additional support in school (i.e. IEP) 21 (50.0%)
SLD 9 (21.4%)
Low self-esteem (per parents’ report) 15 (35.7%)
Very high levels of stress in families 14 (33.3%)
Very high levels of stress between parents 8 (19.0%)