From: Pregnancy in GNE myopathy patients: a nationwide repository survey in Japan
Age | Average [SD] | Median [Min-Max] | |||
Age at survey (yrs) | Participants (n = 44) | 51.0 [11.1] | 49.5 [32-76] | ||
Onset age (yrs)a | 33.0 [9.8] | 30 [16-62] | |||
Maternal age (yrs) | Post-onset pregnancies (n = 28) | 32.5 [4.4] | 31.5 [23-40] | ||
Pre- and post-onset pregnancies (n = 81) | 29.1 [5.0] | 29.0 [19-40] | |||
Genetic diagnosis | Frequency % [95% CI] | ||||
Homozygotesa | Participants (n = 44) | 8.9 [2.5-21.2] | |||
Compound heterozygotesa | 91.1 [78.8-97.5] | ||||
c.620A>T (p.D207V) a | Alleles (n = 88) | 35.2 [25.3-46.1] | |||
c.1807G>C (p.V603L) a | 30.7 [21.3-41.4] | ||||
Parity | n | n | |||
0 | Post-onset pregnancies (n = 28) | 13 | Pre- and post-onset pregnancies (n=81) | 48 | |
1 | 11 | 29 | |||
2 or more | 4 | 4 | |||
Walking ability at pregnancy | Frequency % [95%CI ] | ||||
No assistance | Post-onset pregnancies (n = 27b) | 85.1 [66.2-95.8] | |||
Using assistive devices | 14.8 [4.2-33.7] | ||||
Unable to walk | 0.0 [0.0-12.8] |