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Table 1 Baseline demographic and clinical characteristics at birth in infants included in the case series

From: Characterization of tracheobronchomalacia in infants with hypophosphatasia

Characteristic Patients Who Received Asfotase Alfa as Part of the ENB-010-10 Study Patient Who Received Asfotase Alfa Through Compassionate-Use Program Patient Who Received Asfotase Alfa as Licensed Medication Post-Authorization
Patient 1 Patient 2 Patient 3 Patient 4 Patient 5
Sex Male Male Female Female Female
Ethnicity White Caucasian White Caucasian White Caucasian Asian-Pakistani White Caucasian
Gestational age Term Term 35 weeks, 4 days 34 weeks Term
Birth weight 2.89 kg 3.46 kg 3.06 kg 1.69 kg 3.46 kg
Post-birth respiratory support CPAP ventilation at birth; intubation and ventilation starting at 4 weeks Intubation and ventilation Intubation and ventilation Intubation and ventilation: surfactant Intubation and ventilation at birth
Presence of skeletal manifestations of HPP Yes Yes Yes Yes Yes
Presence of hypotonia Yes Yes Yes Yes Yes
Presence of feeding difficulty Yes Yes Yes Yes Yes
  1. CPAP Continuous positive airway pressure, HPP Hypophosphatasia