Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva

Table 6 ECG and Echocardiogram of Patients with FOP. Results of ECG and trans thoracic echocardiograms of patients from both the NHS study and those not enrolled in the study (*, but still with the classic ACVR1 R206H mutation for FOP)

Patient	Age	ECG Result	Echo Result
1	4	Abnormal Rate of Ventricular Extrasystoles	Normal
2	6	Sinus Tachycardia Right Incomplete Bundle Branch Block	Normal
3	6	Sinus Tachycardia Right Incomplete Bundle Branch Block	Normal
4	7	Normal	Normal
5	7	Normal	Normal
6	15	Intraventricular Conduction Delay	Normal
7	16	Normal	Normal
8	17	Right Bundle Branch Block	Normal
9	17	Right Axis Deviation	Mild Mitral Valve Prolapse
10	18	Intraventricular Conduction Delay	Mild Mitral Regurgitation
11	19	Normal	Mild Mitral Valve Prolapse
12	26	Normal	Mild Mitral Valve Prolapse
13	29	Right Axis Deviation	Normal
14	6*	Normal	Normal
15	11*	First Degree AV Block	Normal
16	16*	Normal	Mitral Dysplasia
17	16*	Normal	Normal
18	17*	Sinus Tachycardia Right Incomplete Bundle Branch Block	Normal
19	17*	Normal	Mitral Insufficiency
20	21*	Normal	Mitral Dysplasia (ballooning)
21	27*	Normal	Pericarditis
22	35*	Normal	Normal

ISSN: 1750-1172