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Table 5 Baseline and Month 12 CAJIS Scores of the NHS Cohort, by ECG category. Mean CAJIS scores of baseline data and 12 month follow up data based on ECG classification. * represent significant differences from CAJIS scores of the Normal ECG subgroup (p < 0.05). Scores were obtained by assigning each joint/region as: 0 = uninvolved; 1 = partially involved; 2 = completely ankylosed. Total (cumulative) scores ranged from 0 to 30, with higher scores indicating more severe limitations in mobility and function

From: Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva

  Baseline Data 12 Month Follow Up Data
  Normal ECG (N = 44) Abnormal ECG (N = 61) Conduction Abnormality (N = 47) Normal ECG (N = 42) Abnormal ECG (N = 54) Conduction Abnormality (N = 41)
Total 12.15 ± 5.52 11.92 ± 6.52 11.21 ± 6.52 13.55 ± 7.41 11.65 ± 7.05 9.93 ± 6.17*
Cervical Spine 1.43 ± 0.65 1.51 ± 0.56 1.38 ± 0.57 1.59 ± 0.58 1.37 ± 0.59 1.27 ± 0.59*
Jaw 0.77 ± 0.88 0.70 ± 0.84 0.53 ± 0.74 0.86 ± 0.91 0.69 ± 0.81 0.56 ± 0.70
Thoraco-Lumbar Spine 1.66 ± 0.56 1.46 ± 0.64 1.36 ± 0.67* 1.71 ± 0.50 1.44 ± 0.71 1.29 ± 0.74*
Left Ankle 0.55 ± 0.69 0.52 ± 0.69 0.43 ± 0.64 0.67 ± 0.68 0.56 ± 0.68 0.49 ± 0.67
Left Elbow 0.75 ± 0.80 0.70 ± 0.73 0.64 ± 0.70 0.71 ± 0.80 0.67 ± 0.72 0.49 ± 0.59
Left Hip 0.86 ± 0.79 0.87 ± 0.80 0.73 ± 0.74 1.17 ± 0.75 0.78 ± 0.79* 0.63 ± 0.69*
Left Knee 0.41 ± 0.61 0.49 ± 0.76 0.34 ± 0.63 0.50 ± 0.73 0.56 ± 0.74 0.49 ± 0.74
Left Shoulder 1.20 ± 0.69 1.23 ± 0.69 1.11 ± 0.66 1.38 ± 0.65 1.13 ± 0.75 0.95 ± 0.73*
Left Wrist 0.27 ± 0.54 0.34 ± 0.54 0.28 ± 0.49 0.21 ± 0.46 0.33 ± 0.51 0.29 ± 0.45
Right Ankle 0.55 ± 0.72 0.56 ± 0.83 0.40 ± 0.61 0.62 ± 0.79 0.57 ± 0.71 0.54 ± 0.70
Right Elbow 0.80 ± 0.76 0.67 ± 0.80 0.57 ± 0.74 0.81 ± 0.88 0.65 ± 0.77 0.46 ± 0.67
Right Hip 0.86 ± 0.89 0.89 ± 0.77 0.72 ± 0.71 1.02 ± 0.86 0.89 ± 0.81 0.73 ± 0.73
Right Knee 0.590 ± 0.81 0.43 ± 0.73 0.28 ± 0.57 0.52 ± 0.76 0.54 ± 0.69 0.46 ± 0.67
Right Shoulder 1.23 ± 0.70 1.26 ± 0.72 1.11 ± 0.72 1.40 ± 0.69 1.20 ± 0.70 1.05 ± 0.70*
Right Wrist 0.23 ± 0.47 0.28 ± 0.52 0.21 ± 0.46 0.36 ± 0.65 0.28 ± 0.49 0.22 ± 0.47