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Fig. 5 | Orphanet Journal of Rare Diseases

Fig. 5

From: Integration of clinical parameters, genotype and epistaxis severity score to guide treatment for hereditary hemorrhagic telangiectasia associated bleeding

Fig. 5

Patients prescribed pharmacologic therapy have higher ESS, which is reduced with antifibrinolytic therapy over time. (a) Patients not assigned to pharmacologic therapy (n = 101) have significant lower ESS compared to patients assigned to either aminocaproic acid (Amicar, n = 14) or tranexamic acid (TA, n = 11). Values represent median ± 5–95% confidence interval, p-values determined by one-way ANOVA with Sidak post-hoc test. (b) Follow up was obtained on 24 patients with median time of 14.5 months. The minimal important difference in ESS is considered to be − 0.71 as noted by dashed line. All patients had a decrease in ESS over time. Compared to patients not on therapy (n = 8), patients whom took either amicar (n = 12) or tranexamic acid (n = 4) had larger reduction of ESS. Values are represented as median ± 95% CI

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