Skip to main content

Table 1 Demographic features of autoimmune pulmonary alveolar proteinosis (aPAP) patients at baseline

From: Inhaled granulocyte-macrophage colony stimulating factor for mild-to-moderate autoimmune pulmonary alveolar proteinosis - a six month phase II randomized study with 24 months of follow-up

Parameter Control group
(n = 17)
Treatment group (n = 19) P value
Age (year) 42.88 ± 12.75 43.53 ± 12.89 0.881
Sex (female/male) 4/13 6/13 0.717
Duration of the disease (months)a 6 (6–60) 6 (0.5–60) 0.852
Smoking status Never 7 7 0.965
Ex-smoker 5 6
Current smoker 5 6
Disease Severity Score 1 0 0 0.409
2 13 11
3 4 8
Hb (g/dL) 16.11 ± 1.61 16.00 ± 1.64 0.839
HCT (%) 46.07 ± 3.7 45.74 ± 4.47 0.810
LDH (U/L) 244.06 ± 53.02 233.82 ± 43.43 0.547
CEA (U/L) 5.34 ± 4.96 4.74 ± 3.41 0.678
FEV1 pred (%) 78.09 ± 14.12 79.16 ± 15.68 0.832
FVC pred (%) 79.14 ± 13.42 79.71 ± 13.70 0.900
TLC pred (%) 74.59 ± 9.65 74.82 ± 10.78 0.946
DLCO pred (%) 69.50 ± 13.94 68.41 ± 16.90 0.835
DLCO/VA pred (%) 98.58 ± 18.45 98.67 ± 24.32 0.990
PaO2 (mmHg) 77.51 ± 8.53 76.88 ± 11.23 0.854
A-aDO2 (mmHg) 28.32 ± 9.09 28.74 ± 11.04 0.902
SGRQ symptom 24.06 ± 13.55 29.17 ± 29.75 0.506
SGRQ activity 30.70 ± 18.46 30.33 ± 16.55 0.949
SGRQ effect 24.20 ± 16.10 21.83 ± 21.29 0.712
SGRQ total 26.47 ± 14.74 27.38 ± 19.75 0.878
6MWD 495.25 ± 79.39 477.95 ± 65.68 0.485
SpO2 at the end of 6MWD 94.87 ± 2.70 94.58 ± 5.20 0.847
Mean lung density − 718.62 ± 82.70 − 687.25 ± 68.48 0.315
Total lung volume radiological measurement (ml) 4556.08 ± 841.15 4461.08 ± 1399.60 0.841
GM-CSF antibody (μ g/ml) 75.86 ± 93.94 73.30 ± 58.65 0.922
Treatment before the trial Never 13 14 0.489
WLL 3 5
Othersb 1 0
  1. Abbreviations: aPAP autoimmune pulmonary alveolar proteinosis, A-aO2 alveolar arterial oxygen gradient, CEA carcinoembryonic antigen, DLCO: DLCO: diffusing capacity for carbon monoxide, DLCO/VA diffusing capacity for carbon monoxide corrected for alveolar volume, FEV1 forced expiratory volume in the first second, FVC forced vital capacity, GM-CSF granulocyte macrophage colony stimulating factor, Hb hemoglobin, HCT hematocrit, LDH lactate dehydrogenase, PaO2 partial pressure of oxygen, SGRQ St George Respiratory Questionnaire, SpO2 oxygen saturation in pulse oximetry, TLC total lung capacity, 6MWD 6 min walking distance (test)
  2. a: median (inter-quartile range)
  3. b:Traditional medicine treatment