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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: Pathologic substrate of gastropathy in Anderson-Fabry disease

Fig. 1

a and b. The light microscopy view of anti-GB3 immunostain of the gastric biopsy sample of the two patients with classical AFD. c and d. Alcian PAS and immunostain of the gastric biopsy with positive immune-reaction (brown) to anti-GB3 antibodies. e Patient 1. Anti-GB3 immunostain showing a ganglion cell (squared by the yellow box and enlarged in the inset) of the submucosal plexus with foam cytoplasm only mildly immunoreactive with anti-GB3 antibodies, surrounded by intensely immunostained neurilemmal cells. f Light microscopy view of negative anti-GB3 immunostain of a sample of the gastric biopsy from patient 5. Identical results were obtained in patients 3, 4, and 6 (Bars provide the original magnification scale)

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