Table 2 Baseline wound characteristics of the vehicle group
From: Wound closure in epidermolysis bullosa: data from the vehicle arm of the phase 3 ESSENCE Study
Total n = 87 | Age Group | Target Wound Age | BSAi of Total Body Wound Burden | EB Type | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 month to <2 years n = 6 | 2 years to <12 years n = 47 | 12 years to <18 years n = 12 | ≥18 years n = 22 | ≤30 days n = 25 | >30 days n = 62 | <5% n = 31 | ≥5% n = 55 | Simplex n = 8 | Recessive dystrophic n = 62 | Intermediate junctional n = 17 | ||
Target Wound Size, cm2 | ||||||||||||
Mean ± SD | 22.0 ± 31.7 | 15.8 ± 6.4 | 25.1 ± 42.2 | 19.3 ± 11.2 | 18.4 ± 9.5 | 17.0 ± 9.2 | 24.0 ± 37.0 | 14.0 ± 4.7 | 26.5 ± 39.1 | 17.7 ± 6.2 | 23.5 ± 37.1 | 18.4 ± 11.0 |
Median | 15.5 | 14.5 | 16.2 | 14.4 | 15.9 | 12.9 | 16.3 | 12.7 | 17.7 | 16.1 | 16.0 | 12.7 |
Min, Max | 7.8, 302.0 | 10.0, 27.5 | 7.8, 302.0 | 10.0, 45.2 | 10.1, 45.4 | 7.8, 43.1 | 10.0, 302.0 | 7.8, 25.4 | 10.1, 302.0 | 10.1, 27.5 | 7.8, 302.0 | 10.0, 45.4 |
Target Wound Age, days | ||||||||||||
Mean ± SD | 521.0 ±1832.0 | 89.0 ±54.8 | 323.7 ±815.5 | 420.5 ±1025.2 | 1115.1 ±3349.7 | 25.3 ±4.9 | 720.9 ±2142.6 | 107.0 ±157.4 | 763.3 ±2273.5 | 141.0 ±238.7 | 253.4 ±656.2 | 1675.7 ±3821.9 |
Median | 60 | 87 | 55 | 61 | 59 | 26 | 91.5 | 42 | 72 | 59 | 57.5 | 83 |
Min, Max | 8, 14,708 | 21, 1850 | 21, 4262 | 21, 3616 | 8, 14,708 | 8, 30 | 31, 14,708 | 8, 728 | 21, 14,708 | 30, 728 | 21, 3616 | 8, 14,708 |
BSAi of Total Body Wound, % | ||||||||||||
Mean ± SD | 10.5 ± 9.1 | 5.3 ± 3.9 | 11.5 ± 10.2 | 13.2 ± 9.6 | 8.0 ± 6.2 | 7.4 ± 6.2 | 11.7 ± 9.8 | 3.3 ± 1.3 | 14.5 ± 9.1 | 4.6 ± 3.8 | 11.1 ± 9.9 | 10.9 ± 6.9 |
Median | 7.6 | 4.3 | 8.8 | 8.7 | 6.5 | 4.9 | 8.1 | 3.6 | 11.9 | 3.3 | 7.6 | 8.1 |
Min, Max | 0.8, 47.0 | 1.9, 12.8 | 1.0, 47.0 | 2.8, 30.0 | 0.8, 25.0 | 0.8, 25.0 | 1.1, 47.0 | 0.8, 4.9 | 5.3, 47.0 | 1.2, 12.8 | 0.8, 47.0 | 2.8, 25.0 |