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Table 2 Baseline wound characteristics of the vehicle group

From: Wound closure in epidermolysis bullosa: data from the vehicle arm of the phase 3 ESSENCE Study

  Total
n = 87
Age Group Target Wound Age BSAi of Total Body Wound Burden EB Type
1 month to
<2 years
n = 6
2 years to
<12 years
n = 47
12 years to <18 years
n = 12
≥18 years
n = 22
≤30 days
n = 25
>30 days
n = 62
<5%
n = 31
≥5%
n = 55
Simplex
n = 8
Recessive dystrophic
n = 62
Intermediate junctional
n = 17
Target Wound Size, cm2
 Mean ± SD 22.0 ± 31.7 15.8 ± 6.4 25.1 ± 42.2 19.3 ± 11.2 18.4 ± 9.5 17.0 ± 9.2 24.0 ± 37.0 14.0 ± 4.7 26.5 ± 39.1 17.7 ± 6.2 23.5 ± 37.1 18.4 ± 11.0
 Median 15.5 14.5 16.2 14.4 15.9 12.9 16.3 12.7 17.7 16.1 16.0 12.7
 Min, Max 7.8, 302.0 10.0, 27.5 7.8, 302.0 10.0, 45.2 10.1, 45.4 7.8, 43.1 10.0, 302.0 7.8, 25.4 10.1, 302.0 10.1, 27.5 7.8, 302.0 10.0, 45.4
Target Wound Age, days
 Mean ± SD 521.0
±1832.0
89.0
±54.8
323.7
±815.5
420.5
±1025.2
1115.1
±3349.7
25.3
±4.9
720.9
±2142.6
107.0
±157.4
763.3
±2273.5
141.0
±238.7
253.4
±656.2
1675.7
±3821.9
 Median 60 87 55 61 59 26 91.5 42 72 59 57.5 83
 Min, Max 8, 14,708 21, 1850 21, 4262 21, 3616 8, 14,708 8, 30 31, 14,708 8, 728 21, 14,708 30, 728 21, 3616 8, 14,708
BSAi of Total Body Wound, %
 Mean ± SD 10.5 ± 9.1 5.3 ± 3.9 11.5 ± 10.2 13.2 ± 9.6 8.0 ± 6.2 7.4 ± 6.2 11.7 ± 9.8 3.3 ± 1.3 14.5 ± 9.1 4.6 ± 3.8 11.1 ± 9.9 10.9 ± 6.9
 Median 7.6 4.3 8.8 8.7 6.5 4.9 8.1 3.6 11.9 3.3 7.6 8.1
 Min, Max 0.8, 47.0 1.9, 12.8 1.0, 47.0 2.8, 30.0 0.8, 25.0 0.8, 25.0 1.1, 47.0 0.8, 4.9 5.3, 47.0 1.2, 12.8 0.8, 47.0 2.8, 25.0
  1. BSAi Body surface area index, EB Epidermolysis bullosa, SD Standard deviation