Table 1 Baseline patient characteristics of the vehicle group
From: Wound closure in epidermolysis bullosa: data from the vehicle arm of the phase 3 ESSENCE Study
Total n = 87 | Age Group | Target Wound Age | BSAi of Total Body Wound Burden | EB Type | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 month to <2 years n = 6 | 2 years to <12 years n = 47 | 12 years to <18 years n = 12 | ≥18 years n = 22 | ≤30 days n = 25 | >30 days n = 62 | <5% n = 31 | ≥5% n = 55 | Simplex n = 8 | Recessive dystrophic n = 62 | Intermediate junctional n = 17 | ||
Age, years | ||||||||||||
Mean ± SD | 13.9 ± 13.1 | 0.6 ± 0.3 | 6.8 ± 2.9 | 14.5 ± 1.8 | 32.5 ± 12.7 | 15.5 ± 15.8 | 13.3 ± 12.0 | 13.4 ± 15.2 | 14.0 ± 11.9 | 6.7 ± 9.1 | 11.5 ± 9.0 | 26.4 ± 19.1 |
Min, Max | 0.2, 67.0 | 0.2, 1.0 | 2.0, 11.0 | 12.0, 17.0 | 18.0, 67.0 | 0.5, 67.0 | 0.2, 59.0 | 0.2, 67.0 | 0.5, 59.0 | 0.2, 28.0 | 0.5, 48.0 | 2.0, 67.0 |
Sex, n (%) | ||||||||||||
Male | 39 (44.8) | 3 (50.0) | 25 (53.2) | 4 (33.3) | 7 (31.8) | 13 (52.0) | 26 (41.9) | 15 (48.4) | 24 (43.6) | 5 (62.5) | 28 (45.2) | 6 (35.3) |
Female | 48 (55.2) | 3 (50.0) | 22 (46.8) | 8 (66.7) | 15 (68.2) | 12 (48.0) | 36 (58.1) | 16 (51.6) | 31 (56.4) | 3 (37.5) | 34 (54.8) | 11 (64.7) |
EB Type, n (%) | ||||||||||||
Simplex | 8 (9.2) | 3 (50.0) | 4 (8.5) | 0 | 1 (4.5) | 1 (4.0) | 7 (11.3) | 5 (16.1) | 3 (5.5) | 8 (100) | 0 | 0 |
Recessive dystrophic | 62 (71.3) | 3 (50.0) | 38 (80.9) | 10 (83.3) | 11 (50.0) | 18 (72.0) | 44 (71.0) | 23 (74.2) | 39 (70.9) | 0 | 62 (100) | 0 |
Intermediate junctional | 17 (19.5) | 0 | 5 (10.6) | 2 (16.7) | 10 (45.5) | 6 (24.0) | 11 (17.7) | 3 (9.7) | 13 (23.6) | 0 | 0 | 17 (100) |