Skip to main content

Table 5 Association between baseline factors and changes in T1/ECV

From: Prospective cardiovascular magnetic resonance imaging in adults with Alström syndrome: silent progression of diffuse interstitial fibrosis

 

T1 SAX Mid Gradient (ms per Year)

T1 SAX Mid ECV Gradient (pp per Year)

N

Mean ± SD

p-Value

N

Mean ± SD

p-Value

Age at First Scan*

26

−0.137*

0.505*

24

0.169

0.430

Ethnicity

  

0.278

  

0.360

White British

18

26.3 ± 25.2

 

17

1.8 ± 2.5

 

Other

8

12.7 ± 35.9

 

7

0.7 ± 2.6

 

Gender

  

0.112

  

0.864

Male

17

15.5 ± 29.4

 

15

1.4 ± 2.5

 

Female

9

34.5 ± 24.8

 

9

1.6 ± 2.8

 

ACE/ARB

  

0.969

  

0.771

No

6

21.7 ± 56.6

 

5

1.8 ± 2.9

 

Yes

20

22.2 ± 16.0

 

19

1.4 ± 2.5

 

Statins/Fibrates

  

0.103

  

0.121

No

14

30.7 ± 22.5

 

14

2.1 ± 2.8

 

Yes

12

12.1 ± 33.1

 

10

0.5 ± 1.7

 

Hypertension

  

0.930

  

0.117

No

11

21.5 ± 35.6

 

10

0.5 ± 2.4

 

Yes

15

22.5 ± 24.2

 

14

2.1 ± 2.4

 

Hyperlipidaemia

  

0.040

  

0.989

No

11

35.5 ± 21.8

 

11

1.5 ± 2.2

 

Yes

15

12.3 ± 30.1

 

13

1.5 ± 2.8

 

Infantile cardiomyopathy

  

0.710

  

0.904

No

16

20.4 ± 33.0

 

15

1.5 ± 2.9

 

Yes

10

24.9 ± 22.0

 

9

1.4 ± 1.9

 

Diabetes

  

0.764

  

0.132

No

9

19.7 ± 39.3

 

9

0.5 ± 2.5

 

Yes

17

23.4 ± 23.0

 

15

2.1 ± 2.4

 

Insulin resistance (not diabetes)

  

0.752

  

0.870

No

20

21.1 ± 30.2

 

18

1.5 ± 2.6

 

Yes

6

25.5 ± 26.3

 

6

1.3 ± 2.4

 

CKD

  

0.889

  

0.630

No

12

23.0 ± 33.3

 

12

1.2 ± 2.0

 

Yes

14

21.4 ± 25.8

 

12

1.7 ± 3.0

 

Presence of CAD**

  

0.622

  

0.121

No

20

23.5 ± 27.5

 

20

1.0 ± 2.0

 

Yes

3

32.7 ± 44.7

 

3

3.4 ± 4.7

 
  1. Gradients were calculated on a per-patient basis, as described in the methods, with the resulting values reported as mean ± SD, and compared between groups using independent samples t-tests, unless stated otherwise. Only those patients with at least two valid scans for the stated marker were included in the analysis
  2. *Reported as a Spearman’s rho correlation coefficient and p-value. **Excludes N = 3 patients with unknown CAD status. Note that ECV was measured as a percentage, hence gradients are reported in percentage points (pp) per year. Bold p-values are significant at p < 0.05